Michael W. Krause, Ph.D.
Harold Smith, Ph.D. — Illumina sequencing services and bioinformatics
WeiPing Chen, Ph.D. — Bioinformatics
Chithra Keembiyehetty, Ph.D. — Affymetrix array services
The Genomics Core Laboratory was created in January 2003 within the NIDDK’s Office of the Director to provide NIDDK’s investigators with innovative, genome-scale technologies in gene expression and DNA sequencing.
The laboratory currently offers microarray screening using the Affymetrix GeneChip platform and massively parallel sequencing (also known as “next-generation sequencing”) using the Illumina HiSeq2000. These services are available to all NIH investigators, although NIDDK samples have first priority. The user provides samples to the core for processing (including quantification and quality control) and receives datasets with basic statistical and bioinformatic analysis. Front-end support includes assistance with experimental design and advice on sample preparation. Users also have access to several data analysis software packages, and additional bioinformatic support is available from the core’s staff members on a collaborative basis. The core also provides access to real-time PCR for target validation.
NIH staff members are encouraged to contact any of the individuals listed above to discuss the application of core services to their research programs or visit the laboratory in person at Building 8, Room 1A11.