The National Institute of Diabetes & Digestive & Kidney Diseases

1. Studies of patients with extreme forms of insulin resistance including patients with mutations in the insulin receptor, autoantibodies to the insulin receptor and other related problems.

2. Studies in patients with lipoatrophy, including genetic and acquired syndromes. These studies involve genetics, lipotoxicity, insulin resistance, and other related problems . A major clinical trial is underway to determine the effect of leptin therapy on reducing insulin resistance in patients with complete lipodystrophy and extreme forms of insulin resistance.

3. Studies of organic hypoglycemia, including the diagnostic value of proinsulin in insulinoma and studies of diagnosis, localization, and treatment of benign and malignant insulinoma.

1. Musso C, Cochran E, Moran SA, Skarulis MC, Oral EA, Taylor S, Gorden P  Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective.  Medicine (Baltimore) (83): 209-22, 2004. [Full Text/Abstract]

2. Cochran E, Young JR, Sebring N, DePaoli A, Oral EA, Gorden P  Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome.  J Clin Endocrinol Metab (89): 1548-54, 2004. [Full Text/Abstract]

3. Javor ED, Moran SA, Young JR, Cochran EK, DePaoli AM, Oral EA, Turman MA, Blackett PR, Savage DB, O''Rahilly S, Balow JE, Gorden P  Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy.  J Clin Endocrinol Metab (89): 3199-207, 2004. [Full Text/Abstract]

4. Arioglu E, Andewelt A, Diabo C, Bell M, Taylor SI, Gorden P  Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective.  Medicine (Baltimore) (81): 87-100, 2002. [Full Text/Abstract]

5. Oral EA, Ruiz E, Andewelt A, Sebring N, Wagner AJ, Depaoli AM, Gorden P  Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy.  J Clin Endocrinol Metab (87): 3110-7, 2002. [Full Text/Abstract]

6. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A  Leptin-replacement therapy for lipodystrophy.  N Engl J Med (346): 570-8, 2002. [Full Text/Abstract]

7. Hirshberg B Livi A Bartlett DL Libutti SK Alexander HR Doppman JL Skarulis MC Gorden P  Forty-eight-hour fast: the diagnostic test for insulinoma.  J Clin Endocrinol Metab (85): 3222-6, 2000. [Full Text/Abstract]