John A. Hanover Research Images
Calmodulin-dependent nuclear import
The Hexosamine Signaling Pathway: The Nutrient Sensing Hexosamine signaling pathway terminating in O-GlcNAc addition and removal. This pathway may be deregulated in human diseases such as diabetes me
OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cells: Using an antisera to OGT (green) and mitotracker (red) OGT isoforms were shown to be present in nucleus and mitochondria.
Structure of the TPR domain of OGT has similarities to Importin alpha: The X-Ray structure of OGT reveals that is dimer and has an 'asparagine ladder' motif similar to that oportin alpha. The OGT TPR domain allows recognition of a large number of intracellular targets.
O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegans: In C. elegans, insulin-like signaling regulates longevity, stress response and the entry into the diapause state termed dauer. Knockout of ogt-1 leads to reduced dauer formation (insulin hypersensitivity) while knockout of oga-1 results in enhanced dauer formation (insulin resistance).
Hexosamine Signaling and Taopathy: Expression of muttated human tau (V337M) in C. elegans causes a severe uncoordinated motion (unc) phenotype associated with neuronal cell death. When this mutation is crossed to ogt-1(ok430), this phenotype is largely corrected.
Figure 3: Ran and Calmodulin - Dependent Nuclear Transport
Page last updated: December 16, 2008