H. James Hofrichter, Ph.D. : NIDDK

H. James Hofrichter, Ph.D.


LASER BIOPHYSICS AND SPECTROSCOPY SCIENTIFIC CONSULTANT
BIOPHYSICAL CHEMISTRY SECTION
NIDDK, National Institutes of Health
Building 5 , Room 108
5 Memorial Dr.
Bethesda, MD 20892
Tel: 301-496-6033
Fax: 301-496-0825
Email: jameshof@mail.nih.gov

Education / Previous Training and Experience:
B.A., Dartmouth College, 1965
Ph.D., University of Oregon, 1972


Research Statement:

Time-resolved absorption and fluorescence spectroscopy are used to study the dynamics of protein structural changes. Kinetics are initiated both by rapid mixing and by using short laser pulses to either produce photochemistry or to change solution conditions. Molecular models for the protein dynamics are used to fit, analyze, and interpret the measured data.



Selected Publications:

1. Munoz V Thompson PA Hofrichter J Eaton WA  Folding dynamics and mechanism of beta-hairpin formation.  Nature (390): 196-9, 1997. [Full Text/Abstract]

2. Thompson PA Eaton WA Hofrichter J  Laser temperature jump study of the helix<==>coil kinetics of an alanine peptide interpreted with a 'kinetic zipper' model.  Biochemistry (36): 9200-10, 1997. [Full Text/Abstract]

3. Hagen SJ, Hofrichter J, Eaton WA Rate of intrachain diffusion of unfolded cytochrome C. Journal of Physical Chemistry B101(13): 2352-2365, 1997.

4. Chan CK Hu Y Takahashi S Rousseau DL Eaton WA Hofrichter J  Submillisecond protein folding kinetics studied by ultrarapid mixing.  Proc Natl Acad Sci U S A (94): 1779-84, 1997. [Full Text/Abstract]



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Page last updated: December 15, 2008

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