Kenneth Jacobson Research Images : NIDDK

Kenneth Jacobson Research Images

Molecular model of a homodimeric A2A adenosine receptor containing a bound conjugate of a PAMAM (polyamidoamine) dendrimer and an A2A agonist, CGS21680. In this model, the multivalent dendrimer conjugate is able to bridge both binding sites of the dimeric receptor. The carbon atoms of PAMAM and the covalently attached 31 moieties of CGS21680 are colored in green.

Molecular model of a homodimeric A2A adenosine receptor containing a bound conjugate of a PAMAM (polyamidoamine) dendrimer and an A2A agonist, CGS21680. In this model, the multivalent dendrimer conjugate is able to bridge both binding sites of the dimeric receptor. The carbon atoms of PAMAM and the covalently attached 31 moieties of CGS21680 are colored in green.

This dendrimer conjugate potently inhibits the aggregation of human platelets induced by ADP.

Page last updated: May 14, 2009

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