Brian Oliver, Ph.D. : NIDDK

Brian Oliver, Ph.D.


LCDB
DEVELOPMENTAL GENOMICS SECTION
NIDDK, National Institutes of Health
Building 50 , Room 3339
50 South Dr.
Bethesda, MD 20892-8028
Tel: 301-496-5494
Fax: 301-496-5239
Email: oliver@helix.nih.gov

Research Website:


Education / Previous Training and Experience:
Brian Oliver received his Ph.D. from the Case Western Reserve University School of Medicine in 1988 where he worked in the Anthony Mahowald laboratory on oogenesis. He did postdoctoral work on sex determination at Stanford University in the laboratory of Bruce Baker. He took a group leader position at the University of Marseille in 1991 where he focused on germline sex determination. He joined the Laboratory of Cellular and Developmental Biology of NIDDK in 1995, where he is now chief of the section of Developmental Genomics.


Research Statement:

The humble fruit fly, Drosophila melanogaster, is an important model system, boasting facile genetics, complex organ systems, complex behaviors and a sequenced genome. Fruit flies are easy to propagate and require little lab space.

We study sewual dimorphism in Fruit flies.  Distinct female or male gene expression networks elaborate from essentially the same underlying genetic information. This is an outstanding systems biology model for understanding how genotype and environment ultimately give rise to phenotype. Our long-term interest is determining how germ cells differentiate into radically different gametes: sperm or eggs. We use a combination of high-throughput techniques to profile biological processes such as expression, promoter occupancy, and chromatin status in conjunction with computational analysis of genomic sequence. Along the way we are addressing a number of interesting questions highly amenable to genome wide analysis. For example, the fate of stem cells is different niche environments and the nature of X chromosome dosage compensation.


Selected Publications:

Mathias Beller, Carole Sztalryd, Noel Southall, Ming Bell, Herbert Jäckle, Douglas S. Auld, Brian Oliver COPI Complex Is a Regulator of Lipid Homeostasis PLoS Biology 2008. [Full Text/Abstract]

Zhang Y, Sturgill D, Parisi M, Kumar S, Oliver B Constraint and turnover in sex-biased gene expression in the genus Drosophila. Nature(450): 233-7, 2007. [Full Text/Abstract]

Sturgill D, Zhang Y, Parisi M, Oliver B Demasculinization of X chromosomes in the Drosophila genus. Nature(450): 238-41, 2007. [Full Text/Abstract]

Drosophila 12 Genomes Consortium  Evolution of genes and genomes on the Drosophila phylogeny. Nature(450): 203-218, 2007. [Full Text/Abstract]

Hempel LU, Oliver B Sex-specific Doublesex[M] expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol(7): 113, 2007. [Full Text/Abstract]

FitzGerald PC, Sturgill D, Shyakhtenko A, Oliver B, Vinson C Comparative genomics of Drosophila and human core promoters Genome Biology(7): R53, 2006. [Full Text/Abstract]

Gupta V, Parisi M, Sturgill D, Nuttall R, Doctolero M, Dudko OK, Malley JD, Eastman PS, Oliver B Global analysis of X-chromosome dosage compensation. J Biol(5): 3, 2006. [Full Text/Abstract]



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Page last updated: December 17, 2008

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