Alan Neil Schechter, M.D.


MMB
MOLECULAR MEDICINE BRANCH
NIDDK, National Institutes of Health
Building 10 , Room 9N314B
10 Center Dr.
Bethesda, MD 20814
Tel: 301-496-5408
Fax: 301-402-0101
Email: aschecht@helix.nih.gov

Alan Neil Schechter, M.D.

Education / Previous Training and Experience:
B.A., Cornell University, 1959
M.D., Columbia University, 1963


Research Statement:

The research program is currently focused on the interaction of nitric oxide (NO) and hemoglobin with the goal of understanding how NO may be transported by blood and thus act at distal sites - opening up its use as a pharmacological agent. This work has the potential for developing therapies for a variety of ischemic diseases, as well as sickle cell anemia and related hemoglobinopathies in which blood flow is impaired. Other research projects currently underway involve studies of the pathophysiological role of cell-free hemoglobin, cell signalling in the NO pathway and the control of fetal hemoglobin expression.



Selected Publications:

Hunter CJ, Dejam A, Blood AB, Shields H, Kim-Shapiro DB, Machado RF, Tarekegn S, Mulla N, Hopper AO, Schechter AN, Power GG, Gladwin MT Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med (10): 1122-7, 2004. [Full Text/Abstract]

Taniuchi H, Schechter AN, Shiloach J Linderstrom-Lang-Schellman''s model for protein stabilization revisited. Curr Protein Pept Sci (5): 275-86, 2004. [Full Text/Abstract]

Schechter AN, Gladwin MT Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med (348): 1483-5, 2003. [Full Text/Abstract]

Cokic VP, Smith RD, Beleslin-Cokic BB, Njoroge JM, Miller JL, Gladwin MT, Schechter AN Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest (111): 231-9, 2003. [Full Text/Abstract]

Haley JD, Smith DE, Schwedes J, Brennan R, Pearce C, Moore C, Wang F, Petti F, Grosveld F, Jane SM, Noguchi CT, Schechter AN Identification and characterization of mechanistically distinct inducers of gamma-globin transcription. Biochem Pharmacol (66): 1755-68, 2003. [Full Text/Abstract]

Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med (9): 1498-505, 2003. [Full Text/Abstract]

Zborowski M, Ostera GR, Moore LR, Milliron S, Chalmers JJ, Schechter AN Red blood cell magnetophoresis. Biophys J (84): 2638-45, 2003. [Full Text/Abstract]

Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO 3rd, Schechter AN, Gladwin MT Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med (8): 1383-9, 2002. [Full Text/Abstract]

Gladwin MT, Wang X, Reiter CD, Yang BK, Vivas EX, Bonaventura C, Schechter AN S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. J Biol Chem (277): 27818-28, 2002. [Full Text/Abstract]

Cannon RO 3rd, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, Gladwin MT Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest (108): 279-87, 2001. [Full Text/Abstract]

Ikonomi P, Noguchi CT, Miller W, Kassahun H, Hardison R, Schechter AN Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins. Gene (261): 277-87, 2000. [Full Text/Abstract]

Smith RD, Malley JD, Schechter AN Quantitative analysis of globin gene induction in single human erythroleukemic cells. Nucleic Acids Res (28): 4998-5004, 2000. [Full Text/Abstract]

Smith RD, Li J, Noguchi CT, Schechter AN Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. Blood (95): 863-9, 2000. [Full Text/Abstract]

Gladwin MT, Ognibene FP, Pannell LK, Nichols JS, Pease-Fye ME, Shelhamer JH, Schechter AN Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc Natl Acad Sci U S A (97): 9943-8, 2000. [Full Text/Abstract]

Gladwin MT, Shelhamer JH, Schechter AN, Pease-Fye ME, Waclawiw MA, Panza JA, Ognibene FP, Cannon RO 3rd Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc Natl Acad Sci U S A (97): 11482-7, 2000. [Full Text/Abstract]




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Page last updated: December 17, 2008

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