Yang, W., Lee, J. Y. and Nowotny, M. Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity Molecular Cell(22): 5-13, 2006.
Yang, W. Poor base stacking at DNA lesions may initiate recognition by many repair proteins DNA Repair(6): 654-66, 2006.
Nowotny, M. and Yang, W. Stepwise analyses of metal ions in RNase H catalysis: from substrate destabilization to product release EMBO J.(25): 1924-33, 2006.
Lee, J. Y. and Yang, W. UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke Cell (in press), 2006.
Guarné, A., Brendler T., Zhao, Q., Ghirlando, R., Austin, S., and Yang, W. Crystal structure of a SeqA-N filament: implications for DNA replication and chromosome organization EMBO J.(24): 1502-11, 2005.
Nowotny, M., Gaidamakov, S. A., Crouch, R. J., and Yang., W. Crystal structures of RNase H bound to an RNA: substrate specificity and metal-dependent catalysis Cell(121): 1005-16, 2005.
Vaisman A., Ling, H., Woodgate, R., and Yang, W. Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis EMBO J.(24): 2957-67, 2005.
Lee, J. Y., Chang, J., Joseph, N. Ghirlando, R., Desirazu, N. R., and Yang, W. MutH complexed with hemi- and unmethylated DNAs: coupling base recognition and DNA cleavage Molecular Cell(20): 155-66, 2005.
Yang W. Portraits of a Y-family DNA polymerase FEBS Lett.(579): 868-72, 2005.
Ling, H, Sayer, J.M., Plosky, B.S., Yagi, H., Boudsocq, F., Woodgate, R., Jerina, D. M. and Yang, W. Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase PNAS(101): 2265-2269, 2004.
Ling, H, Boudsocq, F., Woodgate, R. and Yang, W. Snapshots of replication through an abasic lesion: structural basis for base substitution and frameshift Molecular Cell(13): 751-762, 2004.
Guarné, A., Ramon-Maiques, S., Wolff, E. M., Ghirlando, R., Hu, X., Miller, J. H., and Yang, W. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair EMBO J.(23): 4134-45, 2004.
Alani, E., Lee, J. Y., Schofield, M. J., Kijas, A. W., Hsieh, P., and Yang, W. Crystal structure and biochemical analysis of the MutS-ADP·BeF3- complex suggests a conserved mechanism for ATP interactions in mismatch repair JBC(278): 16088-16094, 2003.
Junop, M. S., Yang, W., Funchain, P., Clendenin, W. and Miller, J. H. In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination DNA Repair(2): 387-405, 2003.
Hu, X., Machius, M., and Yang. W. Monovalent cation dependence and pre- ference of GHKL ATPases and kinases FEBS Lett.(544): 268-273, 2003.
Ling, H, Boudsocq, F., Plosky, B., Woodgate, R. and Yang, W. Replication of a cis-syn thymine dimer at atomic resolution Nature(424): 1083-1087, 2003.
Guarné, A., Zhao, Q.-H. Ghirlando, R.. and Yang, W. SeqA complexed with hemimethylated DNA: negative modulation of E. coli replication initiation Nat. Struct. Biol.(9): 839-843, 2002.
Junop, M. S., Obmolova, G., Rausch, K., Hsieh, P and Yang, W. Composite active site of an ABC ATPsae: MutS uses ATP to verify mismatch recognition and authorize DNA repair Mol. Cell(7): 1-12, 2001.
Ling, H., Boudsocq, F., Woodgate, R. and Yang, W. Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass Cell(107): 91-102, 2001.
Guarné, A., Junop, M. S. and Yang, W. Structure and function of the N-terminal 40kDa fragment of human PMS2: a monomeric GHL ATPase EMBO J.(20): 5521-5531, 2001.
Junop, M. S., Modesti, M., Guarne, A., Gellert, M. and Yang, W. Crystal structure of the Xrcc4 DNA repair protein and implications for end joining EMBO J.(19): 5962-5970, 2000.
Obmolova, G., Ban, C., Hsieh, P and Yang, W. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA Nature(407): 703-710, 2000.
Ban, C., Junop, M. S. and Yang, W Transformation of MutL by ATP Binding and hydrolysis: a switch in DNA mismatch repair Cell(97): 85-97, 1999.
Ban, C. and Yang, W. Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis Cell(95): 541-552, 1998.
Ban C Yang W Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases. EMBO J (17): 1526-34, 1998. [Full Text/Abstract]
