Computational Model of Human Metabolism and Body Weight Change
Dr. Hall recently proposed a detailed computational model of human metabolism that quantitatively tracks all three dietary macronutrients (i.e., carbohydrate, fat, and protein) and their interactions within the human body. The model describes how diet perturbations result in adaptations of whole-body energy expenditure, fuel selection, and various metabolic fluxes (e.g., lipolysis, lipogenesis, gluconeogenesis, ketogenesis, protein turnover, etc.) that ultimately give rise to changes of body weight and composition on a time scale of days and longer.
This page contains the computational model code described in the following publication:
K.D. Hall. 'Predicting Metabolic Adaptation, Body Weight Change and Energy Intake in Humans.' Am J Physiol. In press
Click Here (zip file, 20kb) to downloaded the model code which can be run using the freely available version of the Berkeley Madonna dynamical systems simulation software: http://www.berkeleymadonna.com
Should you have any accessibility issues with the materials provided on this page, please contact Dr. Hall directly at Tel: 301-402-8248 or Email: Kevinh@niddk.nih.gov