Dr. Jean-Pierre Renou (aka Chip) spent a sabbatical term in LGP in 2001 and again in 2002 to explore downstream target genes activated by the Stat5 and beta-catenin signaling pathways. Chip was instrumental in the development of the mammary cDNA microarray (mammochip) and the establishment of the bioinformatic tools necessary to analyze the data generated from the microarrays. During his time at LGP, Chip succesfully identified and isolated several novel genes downstram of the Stat5 and beta-catenin pathways.
Dr. Renou returned to INRA, Jouy, in November 2001 but will return to LGP on a regular basis to data-mine more cDNA microarrays. In 2002 he moved to INRA in Evry to head the Transcriptome group.
1. Renou, J.-P., Bierie, B., Miyoshi, K., Cui, Y., Djiane, J., Reichenstein, M., Shani, M. and Hennighausen, L. (2003) Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Oncogene, 29, 4594-4610.
2. Bierie, B., Nozawa, M., Renou, J.-P., Shillingford, J.M., Morgan, F., Oka, T., Taketo, M.M., Cardiff, R.D., Miyoshi, K., Wagner, K-U., Robinson, G.W. and Hennighausen, L. (2003).Activation of beta-catenin in prostate epithelium induces hyperplasias andsquamous transdifferentiation. Oncogene 22:3875-3877.
3. Miyoshi, K., Meyer, B., Gruss, P., Cui, Y., Renou, J.-P., Morgan, F.V., Smith, G.H., Reichenstein, M., Shani, M., Hennighausen, L. and Robinson, G.W. (2002). Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol. Endocrinol. 16:2892-2901.
4. Dupont, J., Renou, J.P., Shani, M., Hennighausen, L. and LeRoith, D. (2002). PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. J Clin Invest. 110(:815-825.