Dr. Ling Zhao had joined our laboratory in October of 2000 as a postdoctoral research fellow. Her primary research has focused on elucidating the role of IL-6 family members in the process of mammary gland involution using the techniques of mammary gland transplantation, knockout mice and conditionally targted mice. While a member of our lab Ling and her husband Jos had twins, Anne Xinyi Melenhorst (2.81 kg, 47 cm) and Matthew Xinwei Melenhorst (2.95 kg 51 cm) born on Saturday, July 26th at 10:30pm!
In 2004 Ling left LGP to take a position as Research Fellow at the National Human Genome Research Institute (NHGRI).
Publications while in LGP
1. Zhao, L., Hart, S. Chen, J. Melenhorst, J.J., Bierie, B., Ernst, M., Stewart, C., Schaper, F., Heinrich, P.C., Ullrich, A., Robinson, G.W. and Hennighausen, L. (2004). Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK J. Biol. Chem. 279(42):44093-100
2. Zhao, L., Melenhorst, J.J. and Hennighausen, L. (2002). Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3. Mol. Endocrinol. 16:2902-2912.
3. Humphreys, R.C., Bierie, B., Zhao, L., Raz, R., Levy, D. and Hennighausen L. (2002). Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli. Endocrinology 143:3641-3650.
4. Wu, Y., Yakar, S., Zhao, L., Hennighausen, L. and LeRoith, D. (2002) Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res., 62, 1030-1035.