Diabetes, either through autoimmune destruction of islets in type 1 diabetes or cellular resistance to insulin in type 2 diabetes, leads to hyperglycemia and other metabolic defects. Over time, these metabolic abnormalities cause cell and tissue injury and eventually diseases such as heart attacks, stroke, renal failure, peripheral and autonomic neuropathy, and blindness. An important, but elusive, goal for diabetes research has been therapeutics that would prevent or reverse the cellular injury induced by hyperglycemia. A major obstacle is the limitation of animal models to mimic the complexity and chronicity of the human disease.
Significant advances have taken place in approaches to obtain, store, and study human tissue. A goal of this workshop is to learn from the successes in other diseases and better translate them to diabetes research. Of particular importance to diabetes complications research is the availability of clinical data to inform the human tissue findings. The foundation for any consideration of obtaining human tissue is the scientific need and questions that could be addressed.
Goals of the workshop are:
- Review the current use of human post-mortem tissue for research in diabetes complications and other relevant diseases.
- Review the current knowledge on the human pathology of the development of complications from type 1 and type 2 diabetes.
- Review current approaches to the study of human post-mortem tissue. Although tissue quality, collection techniques, and preservation are important, they will not be part of the focus of the meeting.
- Identify specific research questions that could be addressed with human tissue obtained after death from individuals who have pre-consented to donating tissue and who have medical records that fully characterize their diabetes.
- Develop ideas that could be used for future initiatives from NIH and JDRF.
Workshop Organizing Committee
Matthew D. Breyer, MD, Lilly Research Laboratories
Michael Brownlee, MD, Albert Einstein College of Medicine
Alvin Powers, MD, Vanderbilt University
Kristin M.Abraham, PhD, NIDDK
Michael F. Flessner, MD, PhD, NIDDK
Teresa L. Z. Jones, MD, NIDDK
Christian J. Ketchum, PhD, NIDDK
Helen D. Nickerson, PhD, JDRF
DECEMBER 12, 2011
||Opening Remarks |
Gregory Germino, M.D. Deputy Director, NIDDK
Helen Nickerson, Ph.D., JDRF
||Keynote Address – Impact of Human Tissue on Diabetes Complications Research|
Michael Brownlee, M.D., Albert Einstein College of Medicine
|Advances in Understanding Disease Pathogenesis Using Human Post-mortem Tissue |
||Multiple Sclerosis – Bruce D. Trapp, Ph.D., Cleveland Clinic|
||Atherosclerotic Plaques – Renu Vermani, M.D., CVPath Institute|
||Schizophrenia – Joel E. Kleinman, M.D., Ph.D., National Institute of Mental Health|
||Atherosclerosis – Jan H. N. Lindeman, M.D., Ph.D., Leiden University|
||Dementia – Vahram Haroutunian, Ph.D., Mount Sinai School of Medicine|
||Mitochondria and Neurodegenerative Disease – Douglas C. Wallace, Ph.D., University of Pennsylvania|
||GTEx Program – Jeff Struewing, M.D., M.S., National Human Genome Research Institute|
Adjournment for dinner
|DECEMBER 13, 2011|
|Diabetes Research Using Human Post-mortem Tissue|
Joslin Medalist Program – George King, M.D., Joslin Diabetes Center
JDRF Network for Pancreatic Organ Donors With Diabetes (nPOD) – Mark A. Atkinson, Ph.D., University of Florida
Renal System Biology – Matthias Kretzler, M.D., University of Michigan
|Innovative Approaches to the Study of Human Post-mortem Tissue|
||MALDI Imaging Mass Spectrometry – Richard M. Caprioli, Ph.D., Vanderbilt University|
Vascular Tissue Microarrays – Marc K. Halushka, M.D., The Johns Hopkins University
||Integration of Clinical Data with Biochemical and Genetics Research|
Joshua C. Denny M.D., Vanderbilt University
Breakout Sessions for Specific Diabetic Complications
||Discussion of specific research questions that could be addressed by preconsented post-mortem tissue. The focus should be on the science rather than logistical, procurement, or tissue quality issues. Questions include:
- What is the knowledge base of human pathology studies on the development of complications? Are their gaps in our knowledge?
- What are the similarities and differences between preclinical models and human pathology?
- How do we integrate genomic and epigenomic data?
- How well do the stages of the disease correlate with different pathophysiologic mechanisms?
- What are the best situations for bi-directional investigations between pre-clinical models and human tissue?
- Using human tissue, how can we elucidate factors that retard or advance the development of complications?
||Breakout Sessions |
- Cardiovascular Disease – Jean Schaffer, M.D. Washington University and Renu Virmani, M.D., CVPath Institute (invited) (Co-chairs)
- Islet Damage – Mark Atkinson, Ph.D., University of Florida, and Alvin Powers, M.D. Vanderbilt University (Co-chairs)
- Nephropathy – Charles Alpers, M.D., Washington University, and Matthew Breyer, M.D., Eli Lilly and Company (Co-chairs)
- Neuropathy – Nigel Calcutt, Ph.D., University of California, San Diego, and Eva Feldman, M.D., Ph.D., University of Michigan (Co-chairs)
- Retinopathy – Timothy Kern, Ph.D., Case Western Reserve University, and Hendrik P. N. Scholl, M.D. Johns Hopkins University (Co-Chairs)
- Uropathy – Tom F Lue, M.D., University of California San Francisco and Aruna V. Sarma, Ph.D. M.H.A, University of Michigan (Co-chairs) (Invited)
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For questions concerning program content, contact:
Teresa L. Z. Jones, M.D.
Program Director for Diabetes Complications
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Telephone: (301) 435-2996
For questions concerning logistical information or registration, contact:
The Scientific Consulting Group, Inc.
Phone: (301) 670-4990
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Registration and Logistics
Hyatt Regency Bethesda Hotel
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD 20814
Telephone: (301) 657-1234 or (800) 233-1234
A block of sleeping rooms has been reserved at the Hyatt Regency Bethesda, Bethesda, MD, for out-of-town guests attending the NIDDK Human Tissue for Diabetes Complications Research Meeting on December 12-13, 2011. The Hyatt Regency Bethesda has rooms reserved for guests arriving on Monday, December 12, 2011, and departing on Wednesday, December 14, 2011. The room rate is $211 plus tax per night. You will be responsible for the room cost and your incidental charges upon checkout.
Please contact the Hyatt Regency Bethesda by Monday, November 14, 2011, at (301) 657-1234 or 1 (800) 233-1234, and reference the NIDDK’s Human Tissues Meeting when making your sleeping room reservations. For online registrations, please use the meeting code HTDC at the following link: https://resweb.passkey.com/go/HTDC . Please be certain that the hotel provides you with a confirmation number. After November 14, 2011, the hotel will accept reservations on a space-available basis at the prevailing hotel rate.
When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is at 3:00 p.m., and check-out time is 12:00 noon. If for any reason you need to cancel your hotel reservation, please do so 48 hours in advance of your check-in date.
The Scientific Consulting Group, Inc. (SCG) is providing the logistical support for this meeting. The above information should help you with your planning. If you have any questions, please contact Michelle Watson of SCG by telephone at 301-670-4990 or by email at email@example.com.
From Points North
From I-95: Take I-95 South to I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.From I-270:Take I-270 South to I-495 (Capital Beltway) East toward Washington, DC. Stay in one of the three left lanes. Follow signs for 355 South, a left-lane exit, onto Wisconsin Avenue. Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
From Points South
Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
From Baltimore/Washington International Thurgood Marshall Airport (BWI)
Take Route 195 West to Exit 4 (I-95 South). From I-95 take I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
From Washington Dulles International Airport
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267); get off at Exit 18. Stay to the left on the ramp for Bethesda/Baltimore and proceed toward Bethesda on I-495 (Capital Beltway) for approximately 9 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355 South). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
From Ronald Reagan National Airport
Take the George Washington Parkway North to I-495 (Capital Beltway) and follow the signs to Maryland. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
The Metro System is clean, reliable, and safe. It operates from 5:30 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 2:00 a.m. on Fridays; 8:00 a.m. to 2:00 a.m. on Saturdays; and 8:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map. Station attendants on duty at each station can provide additional information on request. From Union Station or downtown Washington (main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove or Grosvenor. Exit at the Bethesda Metro Station. The Hyatt is directly above the Bethesda Metro Station.
SuperShuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrange for a shuttle by calling 800-258-3826 from the airport.
The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport. Fares may differ during peak travel hours.
From BWI Airport, take the MARC train on the Penn Line to Union Station. Take the Metro Red Line toward Grosvenor or Shady Grove and exit at the Bethesda Metro Station. The hotel is directly above the Bethesda Metro Station.
Self-parking at the hotel is $15 per day/overnight. Valet parking is $20 per day/overnight.
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Page last updated: November 07, 2011