Yale University School of Medicine
Director: James L. Boyer, M.D.
Co-directors: Roberto Groszmann, M.D., James M. Anderson, M.D.
Administrator: JoAnn M. Sullivan
The Yale Digestive Disease Research Core Center is a multidisciplinary Center where the research focus is Liver Structure, Function, and Disease. Twenty-nine independent principal investigators compose the research base. Fifteen departments within the University participate in the Center including the Departments of Medicine, Pediatrics, Pathology, Pharmacology, Diagnostic Radiology, Cellular and Molecular Physiology, Biology, Molecular Biophysics and Biochemistry, Human Genetics, Cell Biology, Surgery, Immunobiology, Lab Medicine, Comparative Medicine, and Epidemiology and Public Health. National and international collaborators provide additional expertise, which enhances the overall impact of the Center's research activity. The Center research base is focused on five major themes:
- Cellular and molecular biology of the hepatocyte;
- Hepatic transport mechanisms;
- Hepatic metabolic functions;
- Studies of splanchnic hemodynamics; and
- Clinical studies of hepatic disorders.
Research activities of the Center are broad and range from fundamental studies of the biology of the hepatocyte to clinical therapeutic trials of immediate clinical relevance to the diagnosis and treatment of chronic human liver disease. The principal goals of the Center are to (1) stimulate multidisciplinary activities; (2) to provide a rich training environment; (3) to foster national and international collaborations; (4) to officially organize time consuming, more costly techniques and procedures, and Core facilities for multiple investigator use; (5) to stimulate basic scientists to become involved in one or more of the Center's research interests; (6) to capitalize on important new research opportunities through pilot feasibility projects; and (7) to create an institutional environment that will greatly amplify progress and answer problems in this important area of digestive disease. To work toward these goals, the Center supports three core facilities as listed below. Finally, an enrichment program provides for a bimonthly research seminar series and occasional Center retreats.
- Cell Isolation
- Molecular Biology