Pancreatic Development, Proliferation and Stem Cells
National Institutes of Health
Bethesda, Maryland
October 18–19, 2001
Speakers
Wendy Baldwin New
Office of the Director,
National Institutes of Health
Morris J. Birnbaum, MD, PhD
University of Pennsylvania, HHMI
Daniel J. Drucker, MD
University of Toronto
Helena Edlund, PhD
University of Umea
Michael S. German, MD
University of California, San Francisco
Markus Grompe, MD
Oregon Health Sciences University
Matthias Hebrok New
University of California, San Francisco
Andrew Holland New
Walter and Eliza Hall Institute
Klaus H. Kaestner, PhD
University of Pennsylvania
C. Ronald Kahn, MD
Joslin Diabetes Center
Yoshiya Kawaguchi New
Vanderbilt University
Eckhard Lammert New
Harvard University
Ronald D. McKay, PhD
NINDS, National Institutes of Health
Raghavendra Mirmira New
University of Virginia
Philip D. Noguchi
Food and Drug Administration
Jon Odorico New
University of Wisconsin
Josina Reddy New
University of California San Francisco Cancer Center
Eric Rulifson New
Stanford University
Nora Sarvetnick, PhD
The Scripps Research Institute
Karl Skorecki New
Rambam Medical Center
Andrew F. Stewart, PhD
University of Pittsburgh
Chris Stoeckert
University of Pennsylvania
Atsushi Suzuki New
University of Tsukuba
Catherine Verfaillie
University of Minnesota
Irving Weissman, MD
Stanford University
Christopher Wright, PhD
Vanderbilt University
Kenneth S. Zaret, PhD
Fox Chase Cancer Center
Agenda
Day One
Thursday, October 18, 2001
7:00 to 8:00 am
Registration and Continental Breakfast
8:00 to 8:15 am
Opening Remarks: Allen Spiegel
8:15 to 8:30 am
Meeting Overview: Douglas Melton
Session I – Pancreatic Development: Endoderm to Islet
Douglas Melton (Moderator)
8:30 to 9:00 am
"Pancreas development from the ventral foregut endoderm"
Kenneth Zaret
9:00 to 9:30 am
"Global and tissue-specific requirements for transcription factors in differentiated pancreatic cells and precursor populations"
Christopher Wright
9:30 to 9:45 am
"PTF-1 p48 is expressed in the common precursor of the exocrine and endocrine pancreas"
Yoshiya Kawaguchi
9:45 to 10:00 am
"Induction of pancreatic differentiation by endothelial signals"
Eckhard Lammert
10:00 to 10:30 am
"Overexpression of FGF10 in the developing pancreas perturbs pancreatic cell differentiation"
Helena Edlund
10:30 to 10:45 am
Break
10:45 to 11:15 am
"The hierarchy of factors controlling beta-cell differentiation"
Michael German
11:15 to 11:30 am
"Manipulation of pancreas development and endocrine cell differentiation by Hedgehog signaling components"
Matthias Hebrok
11:30 to 11:45 am
"Inducible Pdx1 knockout mice for the study of b-cell regeneration and function"
Andrew Holland
11:45 to 12:15 pm
"Isolation and characterization of progenitor populations using antigen specific markers"
Nora Sarvetnick
12:15 to 1:15 pm
Lunch (Box lunches provided)
Session II – Regulation of Beta Cell Mass
Kenneth Polonsky (Moderator)
1:15 to 1:30 pm
Overview
Kenneth Polonsky
1:30 to 1:45 pm
"Glucagon-like peptide-1 and b cell proliferation"
Daniel Drucker
2:00 to 2:30 pm
"Overexpression of active Akt/PKB in the mouse beta cell"
Morris Birnbaum
2:30 to 3:00 pm
"PTH-related protein, hepatocyte growth factor, and placental lactogen: transgenic and viral approaches to enhancing islet mass and function"
Andrew Stewart
3:00 to 3:15 pm
"Bcl-XL expression or ARF deficiency abrogates Myc-induced islet involution and promotes pancreatic b-cell hyperplasia"
Josina Reddy
3:15 to 3:30 pm
"Chromatin structure directs target promoter recognition by the
pancreas development factor, PDX-1"
Raghvendra Mirmira
3:30 to 3:45 pm
"The insulin-producing cells of the Drosophila brain regulate growth and hemolymph carbohydrate homeostasis"
Eric Rufilson
3:45 to 4:00 pm
Break
4:00 to 4:30 pm
"Insulin signaling in beta cell growth and function"
C. Ron Kahn
EPConDB Update
4:30 to 5:10 pm
"Functional genomics of the developing endocrine pancreas
EPConDB: The endocrine pancreas consortium database"
Klaus Kaestner /Chris Stoeckert
5:15 to 7:00 pm
POSTERS WITH RECEPTION
Day Two: Friday
Friday, October 19, 2001
Session III – Therapeutic Potential of Stem Cells
Irving Weissman (Moderator)
8:00 to 8:45 am
"Overview, Hematopoiesis Biology, Transplantation, and Evolution of Stem Cells"
Irving Weissman
8:45 to 9:15 am
"Murine pancreatic liver stem cells (PLSC)"
Markus Grompe
9:15 to 9:45 am
"A path from stem cells in the mammalian nervous
system to diabetes"
Ronald McKay
9:45 to 10:15 am
"Genetic identification of islet precursors"
Douglas Melton
10:15 to 10:30 am
"Embryonic stem cells for study of islet ontogeny and generation of transplantation therapies"
Jon Odorico
10:30 to 10:45 am
"Tracking of Insulin-Expressing Cells Originating from Human Embryonic Stem Cells"
Karl Skorecki
10:45 to 11:00 am
"Prospective isolation and enrichment of pancreatic stem/progenitor cells"
Atsushi Suzuki
11:00 to 11:15 am
Break
11:15 to 11:35 am
"Unexpected multipotency of adult stem cells"
Catherine Verfaillie
11:35 to 11:50 am
"Planning for clinical studies: Perspectives from the FDA"
Philip Noguchi
11:50 to 12:00 noon
"NIH implementation plan for the use of human embryonic stem cells"
Wendy Baldwin
12:00 to 12:15 pm
Closing Remarks
Douglas Melton and Kenneth Polonsky
Page last updated: November 25, 2008
