Organ Innervation Development, Disease, and Repair
Doubletree Hotel
Rockville, Maryland
April 15-16, 2004
Abstract
Organ dysfunction as a consequence of neural defects or injury is a common and debilitating problem. The purpose of this workshop is to focus attention on organ innervation so that impediments to research in this area can be identified. An international group of investigators will convene to discuss innervation during development and disease progression and following injury. Developmental mechanisms underlying neural crest fate specification and migration to specific organs as well as factors that guide these processes and regulate neural survival will be considered. Mechanisms of neural injury, autonomic plasticity, and repair will also be emphasized. The workshop is intended to stimulate collaboration between investigators approaching the topic of organ innervation from developmental, disease, and repair perspectives. The workshop will also include a brainstorming session regarding areas of future scientific opportunity.
Agenda
April 15, 2004
7:30 a.m. Continental Breakfast/Registration
8:30 a.m Welcome and Overview, NIH
Session 1 Early Events: Crest Specification and Migration
Chair: Judith Eisen, PhD, University of Oregon
8:40 a.m. Judith Eisen, PhD, University of Oregon
9:15 a.m. Carol Erickson, PhD, University of California, Davis
9:50 a.m. Gurkirpal S. Sohal, PhD, Medical College of Georgia
10:25 a.m. Speaker to be Determined
11:00 a.m. Break
Session 2 Neural Targeting to or Within Organs
Chair: Michael D. Gershon, MD Columbia University College of Physicians and Surgeons
11:20 p.m. E. Michelle Southard-Smith, PhD, Vanderbilt University
11:55 a.m. Speaker to be Determined
12:30 p.m. Lunch 2:15PM Heather Young, PhD, University of Melbourne
2:50 p.m. Miles Epstein, PhD, University of Wisconsin Medical SchoolVisualization of Enteric Crest Cell Migration in situ with Time Lapse Fluorescence Microscopy
3:25 p.m. Three short talks chosen from abstracts
4:10 p.m. Break
4:30 p.m. Keynote AddressMichael D. Gershon, MD, Columbia University College of Physicians and Surgeons
5:30 p.m. Poster Session and Reception
April 16, 2004
7:00 a.m. Continental Breakfast
Session 3 Neuron Differentiation/Survival
Chair: Janet Keast, BSc, PhD, University of South Wales
8:00 a.m. Tim Cowen, BSc, PhD, University College LondonMechanisms Which Enhance and Inhibit Survival of Adult and Ageing Neurons
8:35 a.m. Janet Keast, BSc, PhD, University of New South WalesNeurturin and GDNF: Their Role in the Development and Maintenance of Pelvic Autonomic Ganglia
9:10 a.m. Robert O. Heuckeroth, MD, PhD, Washington University, St. LouisNeurotrophic Factors and Beyond: Defining Molecular Mechanisms of Enteric Nervous System Development
9:45 a.m. Break
Session 4 Neural Injury/Autonomic Plasticity
Chair: Margaret A. Vizzard, PhD, University of Vermont College of Medicine
10:00 a.m. Margaret A. Vizzard, PhD, University of Vermont College of MedicineNeurochemical Plasticity in Micturition Pathways with Bladder Dysfunction
10:35 a.m. William C. de Groat, PhD, University of Pittsburgh School of Medicine
11:10 a.m. Lori A. Birder, PhD, University of Pittsburgh School of Medicine Effects of Injury/Inflammation on Urothelial Sensor and Transducer Properties
11:45 a.m. Naoki Yoshimura, MD, PhD, University of Pittsburgh School of Medicine
12:20 p.m. Lunch
1:30 p.m. Keynote AddressSean J. Morrison, PhD, University of Michigan Medical Center and Howard Hughes Medical InstituteGut Neural Crest Stem
Cells and Hirschsprung Disease
2:30 p.m. Break
3:00 p.m. Initiative Planning
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