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The Intrauterine Environment

Long- term Consequences for Obesity and Metabolic Disease

Bethesda North Marriott Hotel and Conference Center
North Bethesda, MD
September 26-27, 2005

Summary

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a meeting focusing on the long-term consequences of maternal obesity and diabetes on metabolic disease in the offspring. Potential mechanisms mediating these effects also will be addressed. Basic and clinical investigators will discuss a range of topics including: animal models, neural plasticity, genetics, and epidemiology.

The forum for this meeting is a small number of 30-minute talks, each followed by a 15-minute discussion period. In addition, panel discussions lead by invited facilitators will take place to optimize interchange between speakers and participants.

Agenda

Monday, September 26, 2005
8:00 a.m. Maternal Obesity and Diabetes: Clinical Evidence for Long-Term Consequences in the Offspring
	8:00 a.m.	Maternal Obesity: Short- and Long-Term Risks of Obesity For the Offspring
		Patrick Catalano, MetroHealth Medical Center
	8:45 a.m.	Pre- and Peri-Natal Origins of Obesity and Metabolic Disease: An Epidemiologic Perspective
		Mathew W. Gillman, Harvard Medical School
	9:30 a.m.	Coffee Break
	10:00 a.m.	Long-Term Effects of Infant Feeding on Obesity, Growth, and Metabolic Disease
		Michael Kramer, McGill University
	10:45 a.m.	The Accelerator Hypothesis: Evidence that the Rising Incidence of Type-1 Diabetes, Like That of Type-2, May be Driven by Insulin Resistance From Early Life
		Terry Wilkin, Peninsula Medical School
11:15 a.m.	Panel Discussion: Human Studies: Where do We Stand and What Can We Do?
12:15 a.m.	Lunch (on your own)
1:30 p.m. Animal Models of Maternal Obesity and Diabetes: Long-Term Consequences for Metabolic Disease in the Offspring
	1:30 p.m.	Genetic and Perinatal Factors Which Promote Obesity and Metabolic Disease
		Barry Levin, University of Medicine and Dentistry of New Jersey
	2:15 p.m.	Developmental Programming of Metabolomic Syndrome: What Can We Learn From Rodent Models?
		Lucilla Poston, King's College London
	3:00 p.m.	Coffee Break
	3:30 p.m.	Developmental Programming: Species, Gender, Window of Exposure, and Generational Effects
		Peter Nathanielsz, University of Texas Health Science Center Medical School
	4:15 p.m.	Effects of Maternal Diet- Induced Obesity and Diabetes on the Development of Metabolic Systems in the Offspring: A Non-Human Primate Model
		Kevin Grove, Oregon Health and Science University
4:45 p.m.	Panel Discussion: Optimal Animal Models To Determine Mechanisms and Mediators
5:30 p.m.	Wine and Cheese Reception (Cash Bar)
Tuesday, September 27, 2005
8:00 a.m. Developmental Plasticity of Neural Pathways Regulating Energy Balance
	8:00 a.m.	Leptin and Hypothalamic Development
		Richard Simerly, Oregon Health and Science University
	8:45 a.m.	Perinatal Programming and "Functional Teratogenesis": A Neuro-Endocrine Perspective
		Andreas Plagemann, Charite University of Medicine, Berlin
	9:30 a.m.	Coffee Break
10:00 a.m. Food for Thought: Potential Mechanisms Mediating the Consequences of Maternal Obesity and Diabetes
	10:00 a.m.	Placental Programming: An Early Determinant of Neonatal Obesity
		Sylive Hauguel de Mouzon, MetroHealth Medical Center
	10:45 a.m.	Maternal Obesity and the Intrauterine Development of Epigenotype
		Robert Waterland, Children's Nutrition Research Center, Baylor College of Medicine
	11:30 a.m.	Effects of Maternal Obesity in Rats on Reproductive Outcome and Metabolism of Their Offspring in Adulthood: A Role for Glucocorticoids?
		Barbara Woodside, Concordia University
	12:15 p.m.	Maternal Obesity and Birth Defects
		Jim Mills, National Institute of Child Health and Human Development, National Institutes of Health
12:45 p.m.	Final Panel Discussion: The Top 10 List for Research Objectives
1:30 p.m.	Lunch (on your own) and Adjournment