Chronic Kidney Disease in Children Study (CKiD)

May 2021 Council

Lead Division/Office


Point(s) of Contact

Susan R. Mendley, M.D.; Ziya Kirkali, M.D.

Executive Summary

The Chronic Kidney Disease in Children (CKiD) cohort study is a multi-site, transdisciplinary effort that has made foundational discoveries in understanding childhood kidney disease while creating a platform for additional clinical studies and clinical trials. An External Experts Panel considered CKiD to be unique and valuable and recommended that NIDDK renew this initiative to focus on important knowledge gaps that the study is poised to address: progressive cardiovascular disease, metabolic bone disease, neurocognitive function in teenagers and young adults, and kidney outcomes through the transition from pediatric subspecialty care to adult care. Further, the study will validate estimates of GFR in the youngest patients (infants and children <5 years) using a novel fingerprick assay for directly measured iohexol-based GFR. This renewal will maintain the current platform, which has proved critical for supporting pediatric nephrology research, while integrating it more closely with international cohort studies of childhood CKD to increase overall power. Collaboration and funding support from NHLBI and NICHD will be sought at the same level as in previous years.