Chronic Renal Insufficiency Cohort (CRIC) Study

May 2021 Council

Lead Division/Office


Point(s) of Contact

Tracy Rankin, Ph.D., M.P.H.; Afshin Parsa, M.D., M.P.H.; Kevin Chan, M.D.

Executive Summary

This concept proposes to renew support for the Chronic Renal Insufficiency Cohort (CRIC), a long-standing observational study of individuals with chronic kidney disease (CKD). The goals of the study are to identify risk factors for both progression of kidney disease, as well as those for co-morbidities associated with renal decline. The study team has recruited 5499 participants and continues to follow 3268.  In the most recent project period, the investigative team has employed remote data capture modalities to acquire more granular data on serum creatinine and urine protein, as well as heart rate variability, physical activity, and arrhythmias.  Future opportunities for leveraging this well-phenotyped cohort will focus on expansion of remote data capture and mixed-methods investigations into health disparities that modify CKD outcomes.