https://www.niddk.nih.gov/news News and events from NIDDK-funded research and programs. en {32721E38-C449-4ADA-9E3F-B86D36DE4844} https://www.nih.gov/news-events/news-releases/scientists-discover-potential-treatment-approaches-polycystic-kidney-disease Researchers have shown that dangerous cysts, which form over time in polycystic kidney disease (PKD), can be prevented by a single normal copy of a defective gene. This means the potential exists that scientists could one day tailor a gene therapy to treat the disease. They also discovered that a type of drug, known as a glycoside, can sidestep the effects of the defective gene in PKD. The discoveries could set the stage for new therapeutic approaches to treating PKD, which affects millions worldwide. Thu, 04 Apr 2024 00:00:00 -0400 {3A211711-44F5-4D72-82EB-FE73A4B53A6F} https://www.nih.gov/news-events/news-releases/bariatric-surgery-provides-long-term-blood-glucose-control-type-2-diabetes-remission People with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical management plus lifestyle interventions according to a new study supported by the National Institutes of Health. Tue, 27 Feb 2024 00:00:00 -0500 {A7AE7310-4B7C-4A14-AB47-5C13AA6CD039} https://www.nih.gov/news-events/news-releases/switching-vegan-or-ketogenic-diet-rapidly-impacts-immune-system Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan or a ketogenic (also called keto) diet. Scientists closely monitored various biological responses of people sequentially eating vegan and keto diets for two weeks, in random order. Tue, 30 Jan 2024 00:00:00 -0500 {71603E68-5979-4AF2-A7FE-BEC1EFA6F2FB} https://www.niddk.nih.gov/news/archive/2024/alternatives-race-based-kidney-function-calculations NIDDK-supported research is improving the assessment of kidney function by providing accurate alternatives to race-based tools. Wed, 10 Jan 2024 00:00:00 -0500 {CF9284A7-5C4C-4A28-891E-7E55781CCF09} https://www.niddk.nih.gov/news/archive/2024/celebrating-50th-anniversary-diabetes-research-centers 2023 marked the 50th anniversary of the NIDDK-supported Diabetes Research Centers, which have transformed the field of diabetes research. Wed, 10 Jan 2024 00:00:00 -0500 {9643D314-D46F-4DBD-AA67-3F6D3C6484D5} https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/diabetes-in-america Diabetes in America is the NIDDK’s compilation and assessment of epidemiologic, public health, clinical research, and clinical trial data focused on diabetes. This updated resource, developed by researchers at NIDDK and leading diabetes experts from around the country and world, is a one-stop source for crucial scientific information on diabetes, its complications and treatment, health care utilization, and diabetes prevention in the United States. Wed, 10 Jan 2024 00:00:00 -0500 {A97A7FF7-8A37-428D-A9DF-5B0C3EBCD3FF} https://www.niddk.nih.gov/news/archive/2024/improving-kidney-stone-measurements-automated-systems NIDDK supports research to develop automated, more reliable measurement tools for kidney stone detection. Wed, 10 Jan 2024 00:00:00 -0500 {03811533-8844-4B14-87BC-C0EAD2272CDD} https://www.niddk.nih.gov/news/archive/2024/islet-transplantation-treating-difficult-to-manage-type-1-diabetes-adults Decades of NIH-supported research has led to FDA approval of islet transplantation for a limited subset of people with type 1 diabetes. Wed, 10 Jan 2024 00:00:00 -0500 {CB4D1EDF-E910-4CE2-AC2B-41A747769930} https://www.niddk.nih.gov/news/archive/2024/lower-urinary-tract-symptoms-network-lurn The NIDDK-supported Lower Urinary Tract Symptoms Network has developed tools to better understand the full spectrum of lower urinary tract symptoms. Wed, 10 Jan 2024 00:00:00 -0500 {774B7329-7C3D-4AFB-B4E6-A99346EA4813} https://www.niddk.nih.gov/news/archive/2024/making-new-connections-address-silent-epidemic-nonalcoholic-fatty-liver-disease NIDDK continues to support a highly collaborative research program to better understand NAFLD/NASH and to identify new treatment approaches. Wed, 10 Jan 2024 00:00:00 -0500 {6A47EEF9-1040-4A93-BFE3-1685274D0D8D} https://www.niddk.nih.gov/news/archive/2024/research-aims-triumph-against-childhood-liver-disease NIDDK supports a wide range of research on the liver, including large research networks on specific types of liver disease. Wed, 10 Jan 2024 00:00:00 -0500 {88B40821-23EC-4608-A239-8DA6B16DF618} https://www.niddk.nih.gov/news/archive/2024/special-diabetes-program-25-years-advancing-type-1-diabetes-research In 2023, the Special Statutory Funding Program for Type 1 Diabetes Research (Special Diabetes Program) celebrated 25 years of research progress. Wed, 10 Jan 2024 00:00:00 -0500 {5F82D2C8-1986-4FFA-82F9-9CA45F49DD9D} https://www.nih.gov/news-events/news-releases/new-atlas-human-kidney-cells-help-unlock-kidney-disease-research A study funded by the NIH created the most comprehensive atlas of the human kidney to advance progress in understanding and treating kidney disease. The Kidney Tissue Atlas marks an important milestone for the multicenter study, called the Kidney Precision Medicine Project (KPMP), which began in 2017 with the aim of improving treatment for kidney disease. Wed, 19 Jul 2023 00:00:00 -0400 {0A77E4FB-7D75-4E8B-927A-D33018E8EF68} https://www.niddk.nih.gov/news/archive/2023/identifying-biomarkers-predict-type-1-diabetes New biomarkers have been identified that can predict early stages of type 1 diabetes. Thu, 29 Jun 2023 00:00:00 -0400 {2E37E6BF-501B-438F-874E-736A4939D6F6} https://www.niddk.nih.gov/news/archive/2023/complex-interplay-diet-gut-microbiome-influences-human-health Research showed that eating adequate dietary fiber and minimally processed foods can remodel human gut microbiomes and improve energy balance. Wed, 31 May 2023 00:00:00 -0400 {B31346E1-2889-46AB-865A-E53AF8E4B90D} https://www.niddk.nih.gov/news/archive/2023/uncovering-biological-links-between-stress-inflammatory-bowel-disease-flare-ups Researchers identified biological pathways linking stress to worsening inflammatory bowel disease symptoms. Thu, 25 May 2023 00:00:00 -0400 {BF0AFD3D-6F5B-4F98-B1EC-3CAEC9FC98F4} https://www.niddk.nih.gov/news/archive/2023/expanded-study-diversity-uncovers-new-genetic-risk-factors-inflammatory-bowel-disease Studying the genomes from people of East Asian and European ancestry together has identified new genetic risk factors for inflammatory bowel disease. Mon, 08 May 2023 00:00:00 -0400 {01D02C1E-7E85-4AD3-8306-72AC7D141821} https://www.niddk.nih.gov/news/archive/2023/what-gives-exercise-its-beneficial-effects Researchers working with mice identified proteins that link physical exercise with some of its beneficial effects. Wed, 03 May 2023 00:00:00 -0400 {C6785C85-B6ED-4E17-8150-0618E38A2477} https://www.niddk.nih.gov/news/archive/2023/immune-targeting-drug-improves-insulin-production-alters-autoimmune-response A clinical trial of abatacept demonstrated that the immune-targeting drug did not delay type 1 diabetes diagnosis. Mon, 01 May 2023 00:00:00 -0400 {CFFF76D7-C5E8-4603-B1E2-E1724F845C7F} https://www.nih.gov/news-events/news-releases/being-hospitalized-acute-kidney-injury-may-increase-risk-rehospitalization-death A study supported by the National Institutes of Health found that people who experienced acute kidney injury (AKI) during a hospitalization, including those admitted with AKI or who developed AKI in the hospital, were more likely to revisit the hospital or die shortly after discharge, compared to people hospitalized without AKI. AKI is a sudden loss of kidney function that usually lasts for a short time. The research, funded by NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), was published in the American Journal of Kidney Diseases. Thu, 27 Apr 2023 00:00:00 -0400 {9435B224-82F5-43C2-8CDE-886372DD9F46} https://www.niddk.nih.gov/news/archive/2023/women-with-type-2-diabetes-face-higher-burden-risk-factors-compared-men Women with type 2 diabetes continue to carry a greater burden of cardiometabolic and socioeconomic risk factors than men. Mon, 24 Apr 2023 00:00:00 -0400 {BF83D65C-F451-47F3-87AE-4FE8CCBA442E} https://www.niddk.nih.gov/news/archive/2023/molecular-structures-provide-insight-into-key-players-dna-damage-repair Scientists in NIDDK's Intramural Research Program have found new insights into how damaged DNA is repaired. Wed, 19 Apr 2023 00:00:00 -0400 {9054BF26-61B8-4F43-AABA-D4FA0390B4C4} https://www.niddk.nih.gov/news/archive/2023/how-eating-fasting-regulate-insulin Scientists have learned how eating and fasting prompts mice’s cells to increase or decrease insulin secretion by changing gene activity. Mon, 17 Apr 2023 00:00:00 -0400 {BD3CED87-CF08-4F97-A634-32C2CBF96B1F} https://www.niddk.nih.gov/news/archive/2023/potential-explanation-differences-susceptibility-kidney-complications-diabetes New research in mice identified a genetic factor that may shed light on why some people with diabetes are prone to diabetic kidney disease. Thu, 06 Apr 2023 00:00:00 -0400 {D0AADEE4-A609-41B5-9EBB-47E3EFA6634C} https://www.niddk.nih.gov/news/archive/2023/insights-into-cellular-regulation-chromosome-caps The DNA building block thymidine is an important regulator of telomere length, and this finding may lead to new therapies for telomere-related diseases. Thu, 23 Mar 2023 00:00:00 -0400 {1209ECD3-224E-433E-904D-2A29C433553C} https://www.niddk.nih.gov/news/archive/2023/weight-loss-surgery-that-reprograms-bodys-internal-clock-improve-metabolism-eating-behavior In mice, gastric bypass surgery reprograms the body’s day/night “clock”, affecting eating patterns and improving glucose metabolism. Wed, 22 Mar 2023 00:00:00 -0400 {ED50EA66-7DD6-4420-BDA5-A2B28D0F4E4D} https://www.nih.gov/news-events/news-releases/nih-supported-trial-shows-artificial-pancreas-improves-blood-glucose-control-young-children Artificial pancreas technology improved blood glucose control in young children between ages 2 and 6 with type 1 diabetes, according to the results of the Pediatric Artificial Pancreas (PEDAP) Trial, a 13-week randomized controlled trial conducted at three pediatric diabetes centers across the United States. Wed, 15 Mar 2023 00:00:00 -0400 {F17CFC3C-2B5C-4CB9-9AC6-EAD289F9F146} https://www.niddk.nih.gov/news/archive/2023/link-between-cellular-stress-gut-inflammation A research study revealed how cellular stress in the mouse intestinal lining is linked to chronic inflammatory diseases. Mon, 13 Mar 2023 00:00:00 -0400 {393F15E8-377C-4E9F-8D7C-E6A5464FAD20} https://www.niddk.nih.gov/news/archive/2023/limits-acetaminophen-acetaminophen-opioid-combination-medications Researchers studied the effects of an FDA mandate limiting the amount of acetaminophen in combination opioid- acetaminophen pain relievers. Tue, 07 Mar 2023 00:00:00 -0500 {BB5DCE52-F7B6-48D6-A894-613EC2381E11} https://www.niddk.nih.gov/news/archive/2023/study-shows-that-diabetes-young-people-under-age-20-continues-rise Diabetes diagnoses continue to rise in young people in the U.S., especially among racial and ethnic minority youth. Tue, 28 Feb 2023 00:00:00 -0500 {72C7BB35-2410-4595-A06B-50FF2341148C} https://www.nih.gov/news-events/news-releases/early-anti-vegf-treatment-diabetic-retinopathy-yields-no-benefit-visual-acuity Findings from NIH-supported clinical trial showed early treatment of diabetes slows progression to severe disease, but it did not improve visual acuity compared with treating more severe disease once it developed. Tue, 07 Feb 2023 00:00:00 -0500 {50E4DDC2-33BA-4C2A-9875-EAC79CD9F5D7} https://www.niddk.nih.gov/news/archive/2023/discovering-risks-developing-symptoms-due-ureteral-stent-placement Researchers analyzed symptoms following placement of stents after urinary stone surgery, aiming to understand risk factors for bothersome symptoms. Tue, 17 Jan 2023 00:00:00 -0500 {79BCA972-068C-4A50-A414-CF7E5333552D} https://www.nih.gov/news-events/news-releases/new-3-d-model-offers-insights-into-role-glucose-deadly-kidney-disease A research team supported by the National Institutes of Health has developed a new approach to better understand the biology of polycystic kidney disease (PKD), and often-life-threatening genetic disorder that affects millions worldwide. Scientists combined two ways to model the disorder — organ-in-a-dish and organ-on-a-chip technologies — to show the role of glucose, a sugar commonly found in blood, in forming PKD cysts. Thu, 05 Jan 2023 00:00:00 -0500 {B50E05C6-08B9-4AA8-9D87-B91F3A3A3511} https://www.niddk.nih.gov/news/archive/2023/disrupting-talk-amongst-liver-cells-yields-therapeutic-targets-nonalcoholic-fatty-liver-disease Listening in on how liver cells communicate amongst themselves led to discovery of new therapeutic targets for an advanced stage of nonalcoholic fatty liver disease. Wed, 04 Jan 2023 00:00:00 -0500 {1D20569B-5632-409A-9781-A5C87816CB56} https://www.cdc.gov/media/releases/2022/p1229-future-diabetes-surge.html The number of young people under age 20 with diabetes in the United States is likely to increase more rapidly in future decades, according to a new modeling study published today in Diabetes Care. Thu, 29 Dec 2022 00:00:00 -0500 {87F29C4F-A8FA-4F1F-8999-2C35EDD08BC8} https://www.niddk.nih.gov/news/archive/2022/resolving-key-details-polycystic-kidney-disease-genetics Researchers have clarified what genetic variations can cause polycystic kidney disease in people. Tue, 27 Dec 2022 00:00:00 -0500 {A67A0BF3-6660-4925-97F6-C7490E6D05E7} https://www.niddk.nih.gov/news/archive/2022/new-technologies-help-uncover-unexpected-role-glucose-polycystic-kidney-disease Organ-on-a-chip technology has provided new insight into how glucose uptake affects cyst formation within the kidney. Fri, 23 Dec 2022 00:00:00 -0500 {D5C2604C-7274-4840-9C38-E60E1DDD1EEC} https://www.niddk.nih.gov/news/archive/2022/optimizing-treatment-regimens-adults-with-chronic-hepatitis-b A combination treatment regimen could increase long-term clearance of the hepatitis B virus. Fri, 23 Dec 2022 00:00:00 -0500 {A77554C6-5832-47FB-B387-BDA0BC56A17F} https://www.niddk.nih.gov/news/archive/2022/complex-interplay-among-gut-liver-microbes-metabolic-changes-chronic-hepatitis Recent findings about connections between the gut and the liver in hepatitis C could lead to new treatments for liver disease. Thu, 15 Dec 2022 00:00:00 -0500 {2F0A011F-30FF-4FC0-893B-71A884995E0E} https://www.niddk.nih.gov/news/archive/2022/guts-run-how-microbiome-motivates-exercise Scientists discovered that, in mice, the gut microbiome influences brain activity contributing to motivation to exercise. Wed, 14 Dec 2022 00:00:00 -0500 {11766A83-B2CC-41A6-A720-192D010F2F65} https://www.niddk.nih.gov/news/archive/2022/in-utero-therapy-promising-preventing-prenatal-organ-damage-rare-genetic-disease Treating the rare genetic disorder Pompe disease in utero may halt prenatal organ damage and improve health after birth. Wed, 09 Nov 2022 00:00:00 -0500 {E4755DD5-58E3-4CD0-A5C3-282D64B1C84D} https://www.nih.gov/news-events/news-releases/nih-funded-study-finds-personalized-kidney-screening-people-type-1-diabetes-could-reduce-costs-detect-disease-earlier Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The finding, published in Diabetes Care, provides the basis for the first evidence-based kidney screening model for people with T1D. Wed, 02 Nov 2022 00:00:00 -0400 {358BEC4C-529A-4C28-B7B6-43D2D12E8396} https://www.niddk.nih.gov/news/archive/2022/improved-rna-detection-technique-enhances-ability-monitor-cellular-messages Improvements offer ways to simultaneously track the activity of multiple genes faster and more cheaply. Mon, 24 Oct 2022 00:00:00 -0400 {0926480F-A5A3-4FD3-AEE6-6CA41350B13E} https://www.niddk.nih.gov/news/archive/2022/how-meal-timing-may-reduce-obesity-improve-metabolic-health Mouse study revealed why eating late at night can be linked to weight gain and metabolic disease. Thu, 20 Oct 2022 00:00:00 -0400 {308BBB68-4727-46C4-A006-515D7300E7B3} https://www.niddk.nih.gov/news/archive/2022/probing-molecular-events-linking-kidney-injury-fibrosis New research using two mouse models has investigated how different types of cells respond to kidney injuries. Wed, 19 Oct 2022 00:00:00 -0400 {A79C7A3F-F639-4A46-ACDF-4A5A2EC39BC3} https://www.niddk.nih.gov/news/archive/2022/signals-between-nervous-system-intestinal-cells-control-protective-mucus-layer-production-gut New research in mice points to a possible connection between nerves, intestinal mucus, and gastrointestinal inflammation. Fri, 14 Oct 2022 00:00:00 -0400 {1E29A0A0-99BD-419D-A1C6-8C49F67A7AC9} https://www.niddk.nih.gov/news/archive/2022/novel-liver-organoid-technology-provides-insights-fatty-liver-disease-type-2-diabetes Researchers have used new mini-livers or organoids to study fatty liver disease with or without type 2 diabetes. Thu, 13 Oct 2022 00:00:00 -0400 {11207101-07CC-4D82-B351-C0D35970C063} https://www.niddk.nih.gov/news/archive/2022/substance-produced-gut-following-bariatric-surgery-regulates-metabolic-health-mice New research in mice has identified a way that surgical and dietary weight-loss therapies lead to improvements in metabolic and digestive health. Thu, 13 Oct 2022 00:00:00 -0400 {EDB0D456-65C3-41AA-8613-922C41CFFAE7} https://www.niddk.nih.gov/news/archive/2022/identification-new-potential-therapeutic-approach-blood-disorders New way to restart production of fetal hemoglobin suggests a potential therapy for some inherited blood disorders. Wed, 12 Oct 2022 00:00:00 -0400 {7A408FE8-4287-4CB5-9778-7C2E8A7117CB} https://www.niddk.nih.gov/news/archive/2022/limiting-eating-times-improve-health-people-who-work-around-clock A study showed that time-restricted eating was feasible for people on 24-hour shift schedules and had cardiometabolic benefits. Tue, 04 Oct 2022 00:00:00 -0400