Kevin D. Hall, Ph.D.
Kevin Hall.
Scientific Focus Areas: Clinical Research, Computational Biology, Neuroscience


A selection of recent and significant publications can be viewed below.

Select Publications

Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.
Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M.
Cell Metab (2019 Jul 2) 30:67-77.e3. Abstract/Full Text
Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake.
Hall KD, Guo J, Courville AB, Boring J, Brychta R, Chen KY, Darcey V, Forde CG, Gharib AM, Gallagher I, Howard R, Joseph PV, Milley L, Ouwerkerk R, Raisinger K, Rozga I, Schick A, Stagliano M, Torres S, Walter M, Walter P, Yang S, Chung ST.
Nat Med (2021 Feb) 27:344-353. Abstract/Full Text
Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.
Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L.
Cell Metab (2015 Sep 1) 22:427-36. Abstract/Full Text
Dietary fat restriction affects brain reward regions in a randomized crossover trial.
Darcey VL, Guo J, Courville AB, Gallagher I, Avery JA, Simmons WK, Ingeholm JE, Herscovitch P, Martin A, Hall KD.
JCI Insight (2023 Jun 22) 8. Abstract/Full Text
Quantification of the effect of energy imbalance on bodyweight.
Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, Gortmaker SL, Swinburn BA.
Lancet (2011 Aug 27) 378:826-37. Abstract/Full Text

Additional Publications

Reply to DM Thomas et al.
Guo J, Brager DC, Hall KD.
Am J Clin Nutr (2018 Oct 1) 108:901-902. Abstract/Full Text
The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence.
Hall KD, Guyenet SJ, Leibel RL.
JAMA Intern Med (2018 Aug 1) 178:1103-1105. Abstract/Full Text
Low-carbohydrate diets for the treatment of obesity and type 2 diabetes.
Hall KD, Chung ST.
Curr Opin Clin Nutr Metab Care (2018 Jul) 21:308-312. Abstract/Full Text
Reducing Calories to Lose Weight.
Hall KD, Schoeller DA, Brown AW.
JAMA (2018 Jun 12) 319:2336-2337. Abstract/Full Text
Metabolic Adaptations to Weight Loss.
Hall KD.
Obesity (Silver Spring) (2018 May) 26:790-791. Abstract/Full Text
Simulating long-term human weight-loss dynamics in response to calorie restriction.
Guo J, Brager DC, Hall KD.
Am J Clin Nutr (2018 Apr 1) 107:558-565. Abstract/Full Text
Maintenance of Lost Weight and Long-Term Management of Obesity.
Hall KD, Kahan S.
Med Clin North Am (2018 Jan) 102:183-197. Abstract/Full Text
Did the Food Environment Cause the Obesity Epidemic?
Hall KD.
Obesity (Silver Spring) (2018 Jan) 26:11-13. Abstract/Full Text
Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy.
Hall KD, Sanghvi A, Göbel B.
Obesity (Silver Spring) (2017 Dec) 25:2088-2091. Abstract/Full Text
Increased Physical Activity Associated with Less Weight Regain Six Years After "The Biggest Loser" Competition.
Kerns JC, Guo J, Fothergill E, Howard L, Knuth ND, Brychta R, Chen KY, Skarulis MC, Walter PJ, Hall KD.
Obesity (Silver Spring) (2017 Nov) 25:1838-1843. Abstract/Full Text
A quantitative analysis of statistical power identifies obesity end points for improved in vivo preclinical study design.
Selimkhanov J, Thompson WC, Guo J, Hall KD, Musante CJ.
Int J Obes (Lond) (2017 Aug) 41:1306-1309. Abstract/Full Text
Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.
Hall KD, Guo J.
Gastroenterology (2017 May) 152:1718-1727.e3. Abstract/Full Text
A review of the carbohydrate-insulin model of obesity.
Hall KD.
Eur J Clin Nutr (2017 Mar) 71:323-326. Abstract/Full Text
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity.
Friend DM, Devarakonda K, O'Neal TJ, Skirzewski M, Papazoglou I, Kaplan AR, Liow JS, Guo J, Rane SG, Rubinstein M, Alvarez VA, Hall KD, Kravitz AV.
Cell Metab (2017 Feb 7) 25:312-321. Abstract/Full Text
Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure in Mice.
O'Neal TJ, Friend DM, Guo J, Hall KD, Kravitz AV.
Curr Biol (2017 Feb 6) 27:423-430. Abstract/Full Text
How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake.
Polidori D, Sanghvi A, Seeley RJ, Hall KD.
Obesity (Silver Spring) (2016 Nov) 24:2289-2295. Abstract/Full Text
Response to "Overstated metabolic adaptation after 'The Biggest Loser' intervention".
Hall KD, Kerns JC, Brychta R, Knuth ND.
Obesity (Silver Spring) (2016 Oct) 24:2026. Abstract/Full Text
Weight loss diet studies: we need help not hype.
Freedhoff Y, Hall KD.
Lancet (2016 Aug 27) 388:849-51. Abstract/Full Text
Persistent metabolic adaptation 6 years after "The Biggest Loser" competition.
Fothergill E, Guo J, Howard L, Kerns JC, Knuth ND, Brychta R, Chen KY, Skarulis MC, Walter M, Walter PJ, Hall KD.
Obesity (Silver Spring) (2016 Aug) 24:1612-9. Abstract/Full Text
Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children.
Katan MB, de Ruyter JC, Kuijper LD, Chow CC, Hall KD, Olthof MR.
PLoS One (2016) 11:e0159771. Abstract/Full Text
Modeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets.
Bond ND, Guo J, Hall KD, McPherron AC.
Int J Biol Sci (2016) 12:617-30. Abstract/Full Text
Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders.
MacLeod EL, Hall KD, McGuire PJ.
J Inherit Metab Dis (2016 Jan) 39:17-24. Abstract/Full Text
Prescribing low-fat diets: useless for long-term weight loss?
Hall KD.
Lancet Diabetes Endocrinol (2015 Dec) 3:920-1. Abstract/Full Text
Energy Balance After Sodium-Glucose Cotransporter 2 Inhibition.
Ferrannini G, Hach T, Crowe S, Sanghvi A, Hall KD, Ferrannini E.
Diabetes Care (2015 Sep) 38:1730-5. Abstract/Full Text
Nutrition and the science of disease prevention: a systems approach to support metabolic health.
Bennett BJ, Hall KD, Hu FB, McCartney AL, Roberto C.
Ann N Y Acad Sci (2015 Sep) 1352:1-12. Abstract/Full Text
Increased food energy supply as a major driver of the obesity epidemic: a global analysis.
Vandevijvere S, Chow CC, Hall KD, Umali E, Swinburn BA.
Bull World Health Organ (2015 Jul 1) 93:446-56. Abstract/Full Text
Management of obesity: improvement of health-care training and systems for prevention and care.
Dietz WH, Baur LA, Hall K, Puhl RM, Taveras EM, Uauy R, Kopelman P.
Lancet (2015 Jun 20) 385:2521-33. Abstract/Full Text
Child and adolescent obesity: part of a bigger picture.
Lobstein T, Jackson-Leach R, Moodie ML, Hall KD, Gortmaker SL, Swinburn BA, James WP, Wang Y, McPherson K.
Lancet (2015 Jun 20) 385:2510-20. Abstract/Full Text
NIH working group report: Innovative research to improve maintenance of weight loss.
MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D.
Obesity (Silver Spring) (2015 Jan) 23:7-15. Abstract/Full Text
Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.
Knuth ND, Johannsen DL, Tamboli RA, Marks-Shulman PA, Huizenga R, Chen KY, Abumrad NN, Ravussin E, Hall KD.
Obesity (Silver Spring) (2014 Dec) 22:2563-9. Abstract/Full Text
Order of magnitude misestimation of weight effects of children's meal policy proposals.
Brown AW, Hall KD, Thomas D, Dhurandhar NV, Heymsfield SB, Allison DB.
Child Obes (2014 Dec) 10:542-4. Abstract/Full Text
Quantifying energy intake changes during obesity pharmacotherapy.
Göbel B, Sanghvi A, Hall KD.
Obesity (Silver Spring) (2014 Oct) 22:2105-8. Abstract/Full Text
Dispatch from the field: is mathematical modeling applicable to obesity treatment in the real world?
Brady I, Hall KD.
Obesity (Silver Spring) (2014 Sep) 22:1939-41. Abstract/Full Text
Estimating human energy intake using mathematical models.
Hall KD.
Am J Clin Nutr (2014 Sep) 100:744-5. Abstract/Full Text
Novel mathematical models for investigating topics in obesity.
Dawson JA, Hall KD, Thomas DM, Hardin JW, Allison DB, Heymsfield SB.
Adv Nutr (2014 Sep) 5:561-2. Abstract/Full Text
Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany.
Müller MJ, Baracos V, Bosy-Westphal A, Dulloo AG, Eckel J, Fearon KC, Hall KD, Pietrobelli A, Sørensen TI, Speakman J, Trayhurn P, Visser M, Heymsfield SB.
Obes Rev (2014 Aug) 15:640-56. Abstract/Full Text
Short and long-term energy intake patterns and their implications for human body weight regulation.
Chow CC, Hall KD.
Physiol Behav (2014 Jul) 134:60-5. Abstract/Full Text
Dynamic interplay among homeostatic, hedonic, and cognitive feedback circuits regulating body weight.
Hall KD, Hammond RA, Rahmandad H.
Am J Public Health (2014 Jul) 104:1169-75. Abstract/Full Text
The ventral pallidum and orbitofrontal cortex support food pleasantness inferences.
Simmons WK, Rapuano KM, Ingeholm JE, Avery J, Kallman S, Hall KD, Martin A.
Brain Struct Funct (2014 Mar) 219:473-83. Abstract/Full Text
Why is the 3500 kcal per pound weight loss rule wrong?
Hall KD, Chow CC.
Int J Obes (Lond) (2013 Dec) 37:1614. Abstract/Full Text
Category-specific integration of homeostatic signals in caudal but not rostral human insula.
Simmons WK, Rapuano KM, Kallman SJ, Ingeholm JE, Miller B, Gotts SJ, Avery JA, Hall KD, Martin A.
Nat Neurosci (2013 Nov) 16:1551-2. Abstract/Full Text
Dynamics of childhood growth and obesity: development and validation of a quantitative mathematical model.
Hall KD, Butte NF, Swinburn BA, Chow CC.
Lancet Diabetes Endocrinol (2013 Oct) 1:97-105. Abstract/Full Text
Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions.
Schoeller DA, Thomas D, Archer E, Heymsfield SB, Blair SN, Goran MI, Hill JO, Atkinson RL, Corkey BE, Foreyt J, Dhurandhar NV, Kral JG, Hall KD, Hansen BC, Heitmann BL, Ravussin E, Allison DB.
Am J Clin Nutr (2013 Jun) 97:1413-5. Abstract/Full Text
Diet versus exercise in "the biggest loser" weight loss competition.
Hall KD.
Obesity (Silver Spring) (2013 May) 21:957-9. Abstract/Full Text
Metabolism of mice and men: mathematical modeling of body weight dynamics.
Hall KD.
Curr Opin Clin Nutr Metab Care (2012 Sep) 15:418-23. Abstract/Full Text
Last Reviewed February 2024