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News Release
A research team supported by the National Institutes of Health has developed a new approach to better understand the biology of polycystic kidney disease (PKD), and often-life-threatening genetic disorder that affects millions worldwide. Scientists combined two ways to model the disorder — organ-in-a-dish and organ-on-a-chip technologies — to show the role of glucose, a sugar commonly found in blood, in forming PKD cysts.
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News Release
The number of young people under age 20 with diabetes in the United States is likely to increase more rapidly in future decades, according to a new modeling study published today in Diabetes Care.
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News Release
Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The finding, published in Diabetes Care, provides the basis for the first evidence-based kidney screening model for people with T1D.
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News Release
A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care management among people with type 1 diabetes, a new multicenter clinical trial has found.
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News Release
In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications approved by the U.S. Food and Drug Administration to maintain blood glucose levels in the recommended range.
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News Release
NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in diabetic macular edema.
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Research Update
Research in mice suggests a possible new approach for treating hemochromatosis, a disease in which blood iron levels are too high.
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Research Update
LiverTox is a web-based resource for information on drug-induced liver injury from prescription and OTC drugs, and complementary and alternative medicines.
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Research Update
The NIDDK is committed to overcoming the dearth of minority scientists across its mission areas.
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Research Update
For many decades, the NIDDK and the NIH have supported foundational research to better understand the metabolic dysfunction underlying primary hyperoxaluria type 1.
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News Release
The National Institutes of Health is awarding $170 million over five years, pending the availability of funds, to clinics and centers across the country for a new study that will develop algorithms to predict individual responses to food and dietary routines.
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News Release
The National Institutes of Health has launched the first phase of the Neuromod Prize, a $9.8 million competition to accelerate the development of neuromodulation therapies — targeted treatments that adjust nerve activity to improve organ function.
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Research Update
Diabetic foot ulcers may be preventable through early and intensive control of blood glucose levels in people with type 1 diabetes.
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Research Update
By studying differences between diabetic foot ulcers that heal and those that do not, researchers discovered a subset of cells that promote successful wound healing.
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Research Update
Scientists recently used a new strategy to identify, screen, and test possible new drugs to treat hyperparathyroidism by targeting the parathyroid hormone type 1 receptor protein.
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Research Update
Researchers have identified one way that cells determine which microRNAs to release to affect other cells—an insight that has implications for treating diseases associated with microRNA dysfunction.
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News Release
An intervention shown to help first-time parents prevent childhood obesity has shown spillover effects in second-born children as well, even without further training for the parents.
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Research Update
A new hormone complex couples energy status with regulation of metabolism and may play a role in the development of both type 1 and type 2 diabetes.
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Research Update
Researchers identified byproducts of metabolism that are associated with specific symptoms of uremia—a condition in which poor blood filtration from reduced kidney function leads to a buildup of toxins in the blood.
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Research Update
A genetic variation may help explain susceptibility to urinary tract infections in children.
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Research Update
Researchers have discovered a large network of cellular alterations in people with insulin resistance but without diabetes.
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Research Update
In mice, kidney damage caused by autosomal dominant polycystic kidney disease can largely be reversed by activating the normal version of a faulty gene.
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News Release
In a study supported by the National Institutes of Health, researchers propose changing a key measure in kidney disease diagnosis and treatment to eliminate the use of race as a variable, providing a non-biased kidney function test that does not compromise accuracy. The study suggests use of a blood lab test called cystatin C, which does not vary by a person’s race, to replace the current lab test called creatinine, which does.
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News Release
Diagnosed cases of type 1 and type 2 diabetes are surging among youth in the United States. From 2001 to 2017, the number of people under age 20 living with type 1 diabetes increased by 45%, and the number living with type 2 diabetes grew by 95%.
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News Release
People with type 2 diabetes diagnosed during youth have a high risk of developing complications at early ages and have a greater chance of multiple complications within 15 years after diagnosis. The findings are the culmination of a first-of-its-kind trial funded largely by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health.
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Research Update
A recent report described a previously unknown role of exosomes in progression of polycystic kidney disease and identified a compound capable of delaying cyst growth in mouse models of the disease.
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Research Update
Researchers have identified new regions of the genome associated with type 1 diabetes and potential therapeutic targets.
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News Release
GO MOMs, a new study supported by the National Institutes of Health aims to improve gestational diabetes screening and diagnosis by better understanding blood glucose levels throughout pregnancy.
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Research Update
New analysis of genetic data sets from people in different parts of the world has yielded a wealth of discoveries about the genes affecting control of glucose levels.
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Research Update
New findings could inform strategies to preserve cognitive function in people with type 1 diabetes as they age.
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Research Update
A link between an immune system factor and promotion of blood vessel damage may explain liver injury in people with COVID-19.
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Research Update
Researchers have identified a nerve regeneration pathway that could be targeted to reverse erectile dysfunction caused by surgery.
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Research Update
The virus causing COVID-19 can infect pancreatic β (beta) cells, changing their function.
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Research Update
The protein KIM-1 plays a critical role in progression of diabetic kidney disease and may serve as a promising therapeutic target.
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Research Update
Researchers have developed foods designed to alter the gut microbiome, with an eye toward treating malnutrition and obesity.
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Research Update
A small, short-term clinical trial in postmenopausal women found that dietary supplementation with nicotinamide mononucleotide can improve insulin sensitivity in muscle.
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Research Update
New research has identified changes in the microenvironment of the bone marrow that contributes to the aging process of blood stem cells.
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Research Update
New findings suggest a better test is needed to identify future diabetes risk in people over age 70.
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Research Update
New research has shed light on how known genetic risk factors can contribute to Crohn’s disease and treatment response, opening the door to new treatment approaches.
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News Release
In a clinical trial, early treatment with anti-vascular endothelial growth factor (VEGF) injections slowed diabetic retinopathy, a complication of diabetes that causes damage to the blood vessels of the light-sensitive tissue in the retina.
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Research Update
Coaching and mobile technology might be valuable for helping people with type 2 diabetes take better care of themselves and adopt a better diet by improving interactions with family and friends.
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Research Update
Statement on UNITE from NIDDK Director Dr. Griffin P. Rodgers.
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Research Update
New research in mice has identified which cells of the liver contribute in large part toward maintaining the organ or regenerating it after injury.
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Research Update
A new analysis has revealed regions of the genome linked to both elevated levels of body fat and protection from some of the negative health impacts of obesity.
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News Release
Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19.
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Research Update
2021 marks the 100th anniversary of the discovery of insulin, a hormone required for the body to absorb glucose, the main cellular fuel.
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Research Update
Two groups of scientists have tested lipid nanoparticle approaches in mice to deliver treatments for multiple forms of liver disease.
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Research Update
Over the past two decades, researchers have come to appreciate that not only can similar lower urinary tract symptoms result from different problems within its organs and structures, but that not all symptoms originate in the urinary tract itself.
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Research Update
Basic research to understand the hormones controlling blood glucose levels ultimately led to two very important therapeutics with very different purposes.
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Research Update
Decades of scientific research has advanced understanding of porphyrias and led to treatments for some forms of these potentially severe and debilitating disorders.
