Alan R. Kimmel, Ph.D.

Section Chief: Molecular Mechanisms of Development Section​, Laboratory of Cellular & Developmental Biology

Scientific Focus Areas: Cell Biology, Developmental Biology, Genetics and Genomics, Molecular Biology and Biochemistry

alan.kimmel2@nih.gov Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

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An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium.

Jaiswal P, Meena NP, Chang FS, Liao XH, Kim L, Kimmel AR.

Front Cell Dev Biol (2023) 11:1263316. Abstract/Full Text

Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing.

Meena NP, Kimmel AR.

Elife (2017 May 25) 6. Abstract/Full Text

The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis.

Kimmel AR, Sztalryd C.

Annu Rev Nutr (2016 Jul 17) 36:471-509. Abstract/Full Text

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity.

Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C.

Proc Natl Acad Sci U S A (2001 May 22) 98:6494-9. Abstract/Full Text

Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice.

Kim L, Harwood A, Kimmel AR.

Dev Cell (2002 Oct) 3:523-32. Abstract/Full Text

Additional Publications

Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium.

Jaiswal P, Kimmel AR.

Cells (2025 Apr 1) 14. Abstract/Full Text

Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.

Doncheva AI, Li Y, Khanal P, Hjorth M, Kolset SO, Norheim FA, Kimmel AR, Dalen KT.

J Lipid Res (2023 Dec) 64:100461. Abstract/Full Text

A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum.

Bai W, Wells ML, Lai WS, Hicks SN, Burkholder AB, Perera L, Kimmel AR, Blackshear PJ.

Nucleic Acids Res (2021 Nov 18) 49:11920-11937. Abstract/Full Text

Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia.

Li Y, Torp MK, Norheim F, Khanal P, Kimmel AR, Stensløkken KO, Vaage J, Dalen KT.

Biochim Biophys Acta Mol Cell Biol Lipids (2021 Apr) 1866:158873. Abstract/Full Text

Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex.

Li Y, Khanal P, Norheim F, Hjorth M, Bjellaas T, Drevon CA, Vaage J, Kimmel AR, Dalen KT.

J Lipid Res (2021) 62:100048. Abstract/Full Text

DPF is a cell-density sensing factor, with cell-autonomous and non-autonomous functions during Dictyostelium growth and development.

Meena NP, Jaiswal P, Chang FS, Brzostowski J, Kimmel AR.

BMC Biol (2019 Dec 2) 17:97. Abstract/Full Text

mTORC1/AMPK responses define a core gene set for developmental cell fate switching.

Jaiswal P, Kimmel AR.

BMC Biol (2019 Jul 18) 17:58. Abstract/Full Text

Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.

Mardani I, Tomas Dalen K, Drevinge C, Miljanovic A, Ståhlman M, Klevstig M, Scharin Täng M, Fogelstrand P, Levin M, Ekstrand M, Nair S, Redfors B, Omerovic E, Andersson L, Kimmel AR, Borén J, Levin MC.

Sci Rep (2019 May 6) 9:6909. Abstract/Full Text

An ERK Phosphoproteome Expands Chemotactic Signaling in Dictyostelium.

Kimmel AR.

Dev Cell (2019 Feb 25) 48:421-422. Abstract/Full Text

Integrated actions of mTOR complexes 1 and 2 for growth and development of Dictyostelium.

Jaiswal P, Majithia AR, Rosel D, Liao XH, Khurana T, Kimmel AR.

Int J Dev Biol (2019) 63:521-527. Abstract/Full Text

Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation.

Lee YK, Sohn JH, Han JS, Park YJ, Jeon YG, Ji Y, Dalen KT, Sztalryd C, Kimmel AR, Kim JB.

Diabetes (2018 May) 67:791-804. Abstract/Full Text

Quantification of Live Bacterial Sensing for Chemotaxis and Phagocytosis and of Macropinocytosis.

Meena NP, Kimmel AR.

Front Cell Infect Microbiol (2018) 8:62. Abstract/Full Text

Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.

Feng YZ, Lund J, Li Y, Knabenes IK, Bakke SS, Kase ET, Lee YK, Kimmel AR, Thoresen GH, Rustan AC, Dalen KT.

J Lipid Res (2017 Nov) 58:2147-2161. Abstract/Full Text

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC.

Int J Biochem Cell Biol (2017 Oct) 91:9-13. Abstract/Full Text

Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in Dictyostelium.

Platt JL, Kent NA, Kimmel AR, Harwood AJ.

Genome Res (2017 Apr) 27:591-600. Abstract/Full Text

A Unique High-Throughput Assay to Identify Novel Small Molecule Inhibitors of Chemotaxis and Migration.

Liao XH, Kimmel AR.

Curr Protoc Cell Biol (2017 Mar 3) 74:12.11.1-12.11.13. Abstract/Full Text

Biochemical Responses to Chemically Distinct Chemoattractants During the Growth and Development of Dictyostelium.

Meena NP, Kimmel AR.

Methods Mol Biol (2016) 1407:141-51. Abstract/Full Text

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

Ludtmann MH, Otto GP, Schilde C, Chen ZH, Allan CY, Brace S, Beesley PW, Kimmel AR, Fisher P, Killick R, Williams RS.

J Cell Sci (2014 Apr 1) 127:1576-84. Abstract/Full Text

Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.

Kimmel AR, Sztalryd C.

Curr Opin Lipidol (2014 Apr) 25:110-7. Abstract/Full Text

Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection.

Sztalryd C, Kimmel AR.

Biochimie (2014 Jan) 96:96-101. Abstract/Full Text

Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum.

Platt JL, Rogers BJ, Rogers KC, Harwood AJ, Kimmel AR.

Development (2013 Dec) 140:4926-36. Abstract/Full Text

Analysis of chromatin organization by deep sequencing technologies.

Platt JL, Kent NA, Harwood AJ, Kimmel AR.

Methods Mol Biol (2013) 983:173-83. Abstract/Full Text

Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets.

Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR.

J Cell Sci (2012 Sep 1) 125:4067-76. Abstract/Full Text

TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.

Rosel D, Khurana T, Majithia A, Huang X, Bhandari R, Kimmel AR.

J Cell Sci (2012 Jan 1) 125:37-48. Abstract/Full Text

Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium.

Kim L, Brzostowski J, Majithia A, Lee NS, McMains V, Kimmel AR.

Development (2011 Feb) 138:421-30. Abstract/Full Text

Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

McMains VC, Myre M, Kreppel L, Kimmel AR.

Dis Model Mech (2010 Sep-Oct) 3:581-94. Abstract/Full Text

Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.

Liao XH, Buggey J, Kimmel AR.

J Cell Sci (2010 Mar 15) 123:983-92. Abstract/Full Text

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.

Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C.

J Lipid Res (2010 Mar) 51:468-71. Abstract/Full Text

An orphan nuclear receptor finds a home.

Kimmel AR.

Mol Cell (2010 Jan 29) 37:155-7. Abstract/Full Text

Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.

Borg J, Klint C, Wierup N, Ström K, Larsson S, Sundler F, Lupi R, Marchetti P, Xu G, Kimmel A, Londos C, Holm C.

Endocrinology (2009 Jul) 150:3049-57. Abstract/Full Text

Biochemical responses to chemoattractants in Dictyostelium: ligand-receptor interactions and downstream kinase activation.

Liao XH, Kimmel AR.

Methods Mol Biol (2009) 571:271-81. Abstract/Full Text

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism.

Liao XH, Majithia A, Huang X, Kimmel AR.

Amino Acids (2008 Nov) 35:761-70. Abstract/Full Text

Oscillatory signaling and network responses during the development of Dictyostelium discoideum.

McMains VC, Liao XH, Kimmel AR.

Ageing Res Rev (2008 Jul) 7:234-48. Abstract/Full Text

Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling.

Bokko PB, Francione L, Bandala-Sanchez E, Ahmed AU, Annesley SJ, Huang X, Khurana T, Kimmel AR, Fisher PR.

Mol Biol Cell (2007 May) 18:1874-86. Abstract/Full Text

Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line.

Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, Chan L, Kimmel AR, Londos C.

J Biol Chem (2006 Nov 10) 281:34341-8. Abstract/Full Text

GSK3 at the edge: regulation of developmental specification and cell polarization.

Kim L, Kimmel AR.

Curr Drug Targets (2006 Nov) 7:1411-9. Abstract/Full Text

Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay.

Brzostowski JA, Kimmel AR.

Mol Biol Cell (2006 Oct) 17:4220-7. Abstract/Full Text

The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum.

Rosel D, Kimmel AR.

Eur J Cell Biol (2006 Sep) 85:1023-34. Abstract/Full Text

Generation of multiple knockout mutants using the Cre-loxP system.

Kimmel AR, Faix J.

Methods Mol Biol (2006) 346:187-99. Abstract/Full Text

Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway.

Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C.

J Biol Chem (2005 Dec 30) 280:42841-7. Abstract/Full Text

Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins.

Liu X, Rubin JS, Kimmel AR.

Curr Biol (2005 Nov 22) 15:1989-97. Abstract/Full Text

Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

Naudé B, Brzostowski JA, Kimmel AR, Wellems TE.

J Biol Chem (2005 Jul 8) 280:25596-603. Abstract/Full Text

A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.

Khurana T, Brzostowski JA, Kimmel AR.

EMBO J (2005 Jul 6) 24:2254-64. Abstract/Full Text

Books & Book Chapters

Dictyostelium discoideum: methods and protocols. Methods in Molecular Biology

Kimmel, A.R.

Springer US (2024). Abstract/Full Text

Adipocyte fat mobilization: Regulatory functions involving perilipin 1, adipose triglyceride lipase, and hormone-sensitive lipase. In Encyclopedia of Biological Chemistry, Edition 3 (Ed. J. Jez). pp 492-500

Dalen, K.T. and Kimmel, A.R.

Academic Press/Elsevier Science (2021). Abstract/Full Text

DNA Microarrays Part A: Array Platforms & Wet-Bench Protocols, Methods Enzymol. 410.

Kimmel, A.R. and Oliver, B.

Academic Press/Elsevier Science (2006a). Abstract/Full Text

DNA Microarrays, Part B: Databases and Statistics, Methods Enzymol. 411.

Kimmel, A.R. and Oliver, B.

Academic Press/Elsevier Science (2006b). Abstract/Full Text

Molecular Biology of Dictyostelium Development

Kimmel, A.R.

Alan R. Liss (1988).

Guide to Molecular Cloning Techniques, Methods Enzymol. 152.

Berger, S.L. and Kimmel, A.R.

Academic Press/Elsevier Science (1987). Abstract/Full Text