Neuroimmune Crosstalk in the Gut: Impact on Local, Autonomic, and Gut-Brain Function

Event Details

Purpose

The purpose of the Neuroimmune Crosstalk Workshop is to solicit the perspectives and recommendations of experts in the fields of neurogastroenterology, immunology, and microbiology.

The goal is to inform the professional community and the National Institutes of Health (NIH) on the research needs for advancing the understanding of neuroimmune interactions in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)–relevant areas of interest, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, and gut–brain communication.

NIDDK Internal Committee

Diane Cummings, Ph.D.
Program Director, Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health

Patricia Greenwel, Ph.D.
Program Director, DDN, NIDDK, NIH

R. Dwayne Lunsford, Ph.D.
Program Director, DDN, NIDDK, NIH

Terez Shea-Donohue, Ph.D.
Program Director, DDN, NIDDK, NIH

External Committee

Isaac Chiu, Ph.D.
Harvard University

Brian Gulbransen, Ph.D.
Michigan State University

Kara Margolis, M.D.
NYU Langone Health

Registration Deadline

June 23, 2023

Agenda

Thursday, June 29, 2023

8:30 a.m. – 8:45 a.m.

Introduction

8:45 a.m. – 10:40 a.m.

Session I

Neuroimmune Perspectives
Chairs: Kara Margolis, M.D., New York University and Jakob von Moltke, Ph.D., University of Washington

Neuroimmune/Neuro Perspective
Brian Gulbransen, Ph.D., Michigan State University (Neuroimmune/Neuro Perspective)

Immunoneuro/Immune Perspective
Isaac Chiu, Ph.D., Harvard University (Immunoneuro/Immune Perspective)

Questions and Answers

10:40 a.m. – 10:55 a.m.

Break

10:55 a.m. – 12:30 p.m.

Session II

ENS Development and Immune Crosstalk
Chairs: Julia Ganz, Ph.D., Michigan State University and Laren Becker, M.D., Stanford University

Neurodevelopment Overview
E. Michelle Southard-Smith, Ph.D., Vanderbilt University

Neurogenesis and the Immune System
Jaime Belkind-Gerson, M.D., Children’s Hospital Colorado

Immune Mechanisms and Enterocyte Lineages
Yuki Obata, Ph.D., University of Texas Southwestern

Questions and Answers

12:30 p.m. – 1:30 p.m.

Lunch

1:30 p.m. – 2:50 p.m.

Session III

Visualizing Neuroimmune Interactions
Chairs: Eric Chang, Ph.D., Northwell Health and Hongzhen Hu, Ph.D., Washington University

Enteric Nervous System Imaging
Kristen Smith-Edwards, Ph.D., Mayo Clinic

Peripheral ANS Imaging
Li Ye, Ph.D., The Scripps Research Institute

Brain Imaging
Polina Anikeeva, Ph.D., Massachusetts Institute of Technology

Questions and Answers

2:50 p.m. – 3:05 p.m.

Break

3:05 p.m. – 4:25 p.m.

Session IV

Neuroimmune Communication
Chairs: Gianluca Cipriani, Ph.D., Mayo Clinic and Ruaidhri Jackson, Ph.D., Harvard University

Mechanisms of Neuroimmune Communication (Gut)
Francisco Quintana, Ph.D., Brigham and Women’s Hospital, Harvard University Medical School

Neuroimmune and ENS Function (Homeostasis)
Milena Bogunovic, M.D., Ph.D., University of Massachusetts Chan Medical School

Neuroimmune Signaling Inflammation/Infection
Colin Reardon, Ph.D., University of California, Davis

Questions and Answers

4:25 p.m. – 4:30 p.m.

Closing Remarks

4:30 p.m.

Adjournment of Day 1

Friday, June 30, 2023

8:30 a.m. – 9:50 a.m.

Session V

Neuroimmune Sensation
Chairs: Michael Wheeler, Ph.D., Brigham and Women’s Hospital and Alejandra Mendoza, Ph.D., The Scripps Research Institute

Neuroimmune Epithelial Communication
Chuan Wu, M.D., Ph.D., National Cancer Institute, National Institutes of Health

Innate Immune Cell Sensing
Esther Borges-Florsheim, Ph.D., Arizona State University

Immune Cell Nutrient Sensing
Jhimmy Talbot, Ph.D., Fred Hutchinson Cancer Center

Questions and Answers

9:50 a.m. – 10:00 a.m.

Break

10:00 a.m. – 11:30 a.m.

Session VI

Neuroimmune Interactions along the Gut-Brain Axis
Chairs: Tim Sampson, Ph.D., Emory University School of Medicine and Helen Vuong, Ph.D., University of Minnesota

Gut Brain Communication Overview
Kara Margolis, M.D., NYU Langone Health

Enteroendocrine Cells/ENS Afferents and Gut Brain Communication
Diego Bohorquez, Ph.D., Duke University School of Medicine

ENS Sensing of Microbiome and Gut Brain Communication
Christoph Thaiss, Ph.D., University of Pennsylvania Perelman School of Medicine

Questions and Answers

11:30 a.m. – 11:40 a.m.

Break

11:40 a.m. – 12:45 p.m.

Breakout Sessions
Breakout #1
Breakout #2
Breakout #3

12:45 p.m. – 1:30 p.m.

Breakout Summaries

1:30 p.m.

Closing Remarks and Meeting Adjournment