Genetics of Development & Disease Section

of the Genetics & Biochemistry Branch

Seeking to understand the biology of sphingolipids with the goal of developing therapies for the diseases of sphingolipid metabolism.

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Deletion of GBA in neurons, but not microglia, causes neurodegeneration in a Gaucher mouse model.
Duffy HBD, Byrnes C, Zhu H, Tuymetova G, Lee YT, Platt FM, Proia RL.
JCI Insight (2024 Sep 17) Abstract/Full Text
Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.
Allende ML, Lee YT, Byrnes C, Li C, Tuymetova G, Bakir JY, Nicoli ER, James VK, Brodbelt JS, Tifft CJ, Proia RL.
J Lipid Res (2023 Dec) 64:100463. Abstract/Full Text
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Lab Members

Proia/Tifft Lab Members 2024
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Last Reviewed August 2024