Genetics of Development & Disease Section

of the Genetics & Biochemistry Branch

Seeking to understand the biology of sphingolipids with the goal of developing therapies for the diseases of sphingolipid metabolism.

Select Publications

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.
Allende ML, Lee YT, Byrnes C, Li C, Tuymetova G, Bakir JY, Nicoli ER, James VK, Brodbelt JS, Tifft CJ, Proia RL.
J Lipid Res (2023 Dec) 64:100463. Abstract/Full Text
SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis.
Zhu H, Byrnes C, Lee YT, Tuymetova G, Duffy HBD, Bakir JY, Pettit SN, Angina J, Springer DA, Allende ML, Kono M, Proia RL.
FASEB J (2023 May) 37:e22919. Abstract/Full Text
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Lab Members

Proia Lab Members 2022
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Last Reviewed August 2023