Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Lessons From APOL1 Animal Models.

Yoshida T, Latt KZ, Heymann J, Kopp JB.

Front Med (Lausanne) (2021) 8:762901. Abstract/Full Text

Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease.

Curran CS, Kopp JB.

Front Pharmacol (2022) 13:782199. Abstract/Full Text

Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype.

Yoshida T, Latt KZ, Rosenberg AZ, Shrivastav S, Heymann J, Halushka MK, Winkler CA, Kopp JB.

Kidney Int Rep (2023 Jan) 8:164-178. Abstract/Full Text

Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures.

Latt KZ, Heymann J, Jessee JH, Rosenberg AZ, Berthier CC, Arazi A, Eddy S, Yoshida T, Zhao Y, Chen V, Nelson GW, Cam M, Kumar P, Mehta M, Kelly MC, Kretzler M, Nephrotic Syndrome Study Network (NEPTUNE), Accelerating Medicines Partnership in Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Ray PE, Moxey-Mims M, Gorman GH, Lechner BL, Regunathan-Shenk R, Raj DS, Susztak K, Winkler CA, Kopp JB.

Kidney Int Rep (2022 Feb) 7:289-304. Abstract/Full Text

HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule.

Shrivastav S, Lee H, Okamoto K, Lu H, Yoshida T, Latt KZ, Wakashin H, Dalgleish JLT, Koritzinsky EH, Xu P, Asico LD, Chung JY, Hewitt S, Gildea JJ, Felder RA, Jose PA, Rosenberg AZ, Knepper MA, Kino T, Kopp JB.

PLoS One (2022) 17:e0273313. Abstract/Full Text

Additional Publications

HIV viral protein R induces loss of DCT1-type renal tubules.

Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z, Lee H, Okamoto K, Dagur P, Heymann J, Zhao Y, Chung JY, Hewitt S, Jose PA, Lee K, He JC, Winkler CA, Knepper MA, Kino T, Rosenberg AZ, Susztak K, Kopp JB.

bioRxiv (2023 Nov 13) Abstract/Full Text

Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease.

Beshensky D, Pirsl F, Holtzman NG, Steinberg SM, Mays JW, Cowen EW, Comis LE, Joe GO, Magone MT, Schulz E, Waldman MA, Pavletic SZ.

Bone Marrow Transplant (2023 Oct) 58:1112-1120. Abstract/Full Text

Phenotypes of APOL1 High-Risk Status Subjects.

Kopp JB, Yoshida T.

J Am Soc Nephrol (2023 May 1) 34:735-736. Abstract/Full Text

APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice.

Yoshida T, Latt KZ, Santo BA, Shrivastav S, Zhao Y, Fenaroli P, Chung JY, Hewitt SM, Tutino VM, Sarder P, Rosenberg AZ, Winkler CA, Kopp JB.

bioRxiv (2023 Mar 27) Abstract/Full Text

Prediagnostic Appearance of Thrombospondin Type-1 Domain 7A Autoantibodies in Membranous Nephropathy.

Burbelo PD, Olson SW, Keller JM, Joshi M, Schwartz DM, Chuang YJ, Lambeau G, Beck LH Jr, Waldman M.

Kidney360 (2023 Feb 1) 4:217-225. Abstract/Full Text

Pregnancy History and Kidney Disease Progression Among Women Enrolled in Cure Glomerulonephropathy.

Reynolds ML, Oliverio AL, Zee J, Hendren EM, O'Shaughnessy MM, Ayoub I, Almaani S, Vasylyeva TL, Twombley KE, Wadhwani S, Steinke JM, Rizk DV, Waldman M, Helmuth ME, Avila-Casado C, Alachkar N, Nester CM, Derebail VK, Hladunewich MA, Mariani LH.

Kidney Int Rep (2023 Apr) 8:805-817. Abstract/Full Text

Potential for false decline of anti-SARS-CoV-2 spike antibody titers after COVID-19 vaccination.

Waldman M, Sacks DB, Howard L, Cole J.

Lancet Rheumatol (2022 Sep) 4:e586-e587. Abstract/Full Text

Structural determinants of the dominant conformational epitopes of phospholipase A2 receptor in primary membranous nephropathy.

Tang H, Zhu R, Waldman M, Zhu Q.

J Biol Chem (2022 Mar) 298:101605. Abstract/Full Text

A Novel Predictive Model for Hospital Survival in Patients who are Critically Ill with Dialysis-Dependent AKI: A Retrospective Single-Center Exploratory Study.

Ganguli A, Farooq S, Desai N, Adhikari S, Shah V, Sherman MJ, Veis JH, Moore J.

Kidney360 (2022 Apr 28) 3:636-646. Abstract/Full Text

COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

Waldman M, Soler MJ, García-Carro C, Lightstone L, Turner-Stokes T, Griffith M, Torras J, Martinez Valenzuela L, Bestard O, Geddes C, Flossmann O, Budge KL, Cantarelli C, Fiaccadori E, Delsante M, Morales E, Gutierrez E, Niño-Cruz JA, Martinez-Rueda AJ, Comai G, Bini C, La Manna G, Slon MF, Manrique J, Avello A, Fernandez-Prado R, Ortiz A, Marinaki S, Martin Varas CR, Rabasco Ruiz C, Sierra-Carpio M, García-Agudo R, Fernández Juárez G, Hamilton AJ, Bruchfeld A, Chrysochou C, Howard L, Sinha S, Leach T, Agraz Pamplona I, Maggiore U, Cravedi P.

Kidney360 (2022 Feb 24) 3:293-306. Abstract/Full Text

Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.

Mandl A, Burbelo PD, Di Pasquale G, Tay YS, Welch J, Lionakis MS, Rosenzweig SD, Waldman MA, Warner BM, Walitt B, Collins MT, Balow JE, Chiorini JA, Simonds WF, Agarwal SK, Blau JE, Weinstein LS.

N Engl J Med (2021 Nov 18) 385:1974-1980. Abstract/Full Text

Combined Immunosuppressive Therapy for Severe Graves Dermopathy.

Gubbi S, Araque KA, Avadhanula S, Azam A, Merkel R, Cochran C, Burbelo PD, Waldman M, Neumann S, Gershengorn MC, Skarulis M, Klubo-Gwiezdzinska J.

Ann Intern Med (2021 Oct) 174:1478-1480. Abstract/Full Text

COVID-19 vaccines and kidney disease.

Windpessl M, Bruchfeld A, Anders HJ, Kramer H, Waldman M, Renia L, Ng LFP, Xing Z, Kronbichler A.

Nat Rev Nephrol (2021 May) 17:291-293. Abstract/Full Text

Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome.

Goel RR, Nakabo S, Dizon BLP, Urban A, Waldman M, Howard L, Darnell D, Buhaya M, Carmona-Rivera C, Hasni S, Kaplan MJ, Freeman AF, Gupta S.

J Allergy Clin Immunol (2021 Feb) 147:746-749.e9. Abstract/Full Text

Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring.

Waldman M, Soler MJ, García-Carro C, Lightstone L, Turner-Stokes T, Griffith M, Torras J, Valenzuela LM, Bestard O, Geddes C, Flossmann O, Budge KL, Cantarelli C, Fiaccadori E, Delsante M, Morales E, Gutierrez E, Niño-Cruz JA, Martinez-Rueda AJ, Comai G, Bini C, La Manna G, Slon MF, Manrique J, Agraz I, Sinaii N, Cravedi P.

Kidney Int (2021 Jan) 99:227-237. Abstract/Full Text

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress.

Wakashin H, Heymann J, Roshanravan H, Daneshpajouhnejad P, Rosenberg A, Shin MK, Hoek M, Kopp JB.

BMC Nephrol (2020 Aug 27) 21:371. Abstract/Full Text

COVID-19 and the Kidneys: An Update.

Benedetti C, Waldman M, Zaza G, Riella LV, Cravedi P.

Front Med (Lausanne) (2020) 7:423. Abstract/Full Text

Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20.

Schwartz DM, Blackstone SA, Sampaio-Moura N, Rosenzweig S, Burma AM, Stone D, Hoffmann P, Jones A, Romeo T, Barron KS, Waldman MA, Aksentijevich I, Kastner DL, Milner JD, Ombrello AK.

Ann Rheum Dis (2020 Mar) 79:429-431. Abstract/Full Text

Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling.

Faulhaber-Walter R, Jiang L, Mizel D, Zerfas PM, Kopp JB, Schnermann JB, Chen L, Schiffer M.

Int J Nephrol Renovasc Dis (2020) 13:19-26. Abstract/Full Text

Detection of PLA2R Autoantibodies before the Diagnosis of Membranous Nephropathy.

Burbelo PD, Joshi M, Chaturvedi A, Little DJ, Thurlow JS, Waldman M, Olson SW.

J Am Soc Nephrol (2020 Jan) 31:208-217. Abstract/Full Text

Rituximab or Cyclosporine for Membranous Nephropathy.

Waldman M, Austin HA 3rd, Balow JE.

N Engl J Med (2019 Oct 24) 381:1688. Abstract/Full Text

Effects of Metreleptin on Proteinuria in Patients With Lipodystrophy.

Lee HL, Waldman MA, Auh S, Balow JE, Cochran EK, Gorden P, Brown RJ.

J Clin Endocrinol Metab (2019 Sep 1) 104:4169-4177. Abstract/Full Text

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.

Szymanski JM, Waldman M, Conry-Cantilena C, West KA.

J Clin Apher (2019 Aug) 34:495-498. Abstract/Full Text

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.

Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J.

Arthritis Rheumatol (2019 Jul) 71:1135-1140. Abstract/Full Text

One Actor, Many Roles: Histopathologies Associated With APOL1 Genetic Variants.

Kopp JB, Rosenberg AZ.

Adv Anat Pathol (2019 May) 26:215-219. Abstract/Full Text

Health-related quality of life in glomerular disease.

Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Mahan JD, Nachman PH, Selewski DT, Sethna CB, Srivastava T, Tuttle KR, Wang CS, Falk RJ, Gharavi AG, Gillespie BW, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Guay-Woodford LM, Reeve B, Gipson DS, CureGN Consortium.

Kidney Int (2019 May) 95:1209-1224. Abstract/Full Text

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.

Ryu JH, Ge M, Merscher S, Rosenberg AZ, Desante M, Roshanravan H, Okamoto K, Shin MK, Hoek M, Fornoni A, Kopp JB.

PLoS One (2019) 14:e0211559. Abstract/Full Text

Autoantibodies are present before the clinical diagnosis of systemic sclerosis.

Burbelo PD, Gordon SM, Waldman M, Edison JD, Little DJ, Stitt RS, Bailey WT, Hughes JB, Olson SW.

PLoS One (2019) 14:e0214202. Abstract/Full Text

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Mariani LH, Bomback AS, Canetta PA, Flessner MF, Helmuth M, Hladunewich MA, Hogan JJ, Kiryluk K, Nachman PH, Nast CC, Rheault MN, Rizk DV, Trachtman H, Wenderfer SE, Bowers C, Hill-Callahan P, Marasa M, Poulton CJ, Revell A, Vento S, Barisoni L, Cattran D, D'Agati V, Jennette JC, Klein JB, Laurin LP, Twombley K, Falk RJ, Gharavi AG, Gillespie BW, Gipson DS, Greenbaum LA, Holzman LB, Kretzler M, Robinson B, Smoyer WE, Guay-Woodford LM, CureGN Consortium.

Am J Kidney Dis (2019 Feb) 73:218-229. Abstract/Full Text

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

Mastellos DC, Reis ES, Biglarnia AR, Waldman M, Quigg RJ, Huber-Lang M, Seelen MA, Daha MR, Lambris JD.

Clin Immunol (2019 Jan) 198:102-105. Abstract/Full Text

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol (2018) 1:188. Abstract/Full Text

Alström syndrome: Renal findings in correlation with obesity, insulin resistance, dyslipidemia and cardiomyopathy in 38 patients prospectively evaluated at the NIH clinical center.

Waldman M, Han JC, Reyes-Capo DP, Bryant J, Carson KA, Turkbey B, Choyke P, Naggert JK, Gahl WA, Marshall JD, Gunay-Aygun M.

Mol Genet Metab (2018 Sep) 125:181-191. Abstract/Full Text

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R.

J Clin Invest (2018 Jul 2) 128:3041-3052. Abstract/Full Text

ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2.

Lee H, Roshanravan H, Wang Y, Okamoto K, Ryu J, Shrivastav S, Qu P, Kopp JB.

Am J Physiol Renal Physiol (2018 Jul 1) 315:F140-F150. Abstract/Full Text

APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.

Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA.

Circ Genom Precis Med (2018 Jun) 11:e002098. Abstract/Full Text

Apolipoprotein L1 nephropathies: 2017 in review.

Kopp JB, Roshanravan H, Okamoto K.

Curr Opin Nephrol Hypertens (2018 May) 27:153-158. Abstract/Full Text

APOL1 nephropathy risk variants do not associate with subclinical atherosclerosis or left ventricular mass in middle-aged black adults.

Gutiérrez OM, Limou S, Lin F, Peralta CA, Kramer HJ, Carr JJ, Bibbins-Domingo K, Winkler CA, Lewis CE, Kopp JB.

Kidney Int (2018 Mar) 93:727-732. Abstract/Full Text

Does TSH Reliably Detect Hypothyroid Patients?

Ling C, Sun Q, Khang J, Felipa Lastarria M, Strong J, Stolze B, Yu X, Parikh TP, Waldman MA, Welsh K, Jonklaas J, Masika L, Soldin SJ.

Ann Thyroid Res (2018) 4:122-125. Abstract/Full Text

Renal Fanconi syndrome with meropenem/amoxicillin-clavulanate during treatment of extensively drug-resistant tuberculosis.

Abadie ME, Strich JR, Kim T, Xie YL, Fennelly KP, Olivier KN, Waldman M, Arora K, Holland SM, Chen RY.

Eur Respir J (2017 Dec) 50. Abstract/Full Text

Kidney Diseases Associated with Human Immunodeficiency Virus Infection.

Cohen SD, Kopp JB, Kimmel PL.

N Engl J Med (2017 Dec 14) 377:2363-2374. Abstract/Full Text

APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.

Kopp JB, Heymann J, Winkler CA.

Semin Nephrol (2017 Nov) 37:514-519. Abstract/Full Text

Chronic Kidney Disease in the Aging Human Immunodeficiency Virus-Infected Population.

Kopp JB.

J Infect Dis (2017 Sep 15) 216:619-621. Abstract/Full Text

APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death.

Hughson MD, Hoy WE, Mott SA, Bertram JF, Winkler CA, Kopp JB.

Kidney Int Rep (2018 Jan) 3:89-98. Abstract/Full Text

A tripartite complex of suPAR, APOL1 risk variants and α(v)β(3) integrin on podocytes mediates chronic kidney disease.

Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J.

Nat Med (2017 Aug) 23:945-953. Abstract/Full Text

Sickle Cell Trait and the Risk of ESRD in Blacks.

Naik RP, Irvin MR, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR, Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp JB, Winkler CA, Cushman M.

J Am Soc Nephrol (2017 Jul) 28:2180-2187. Abstract/Full Text