Using chemical biology to develop new tools to interrogate cell surface proteins and their signaling

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Chemically Induced Dimerization via Nanobody Binding Facilitates in Situ Ligand Assembly and On-Demand GPCR Activation.
Saha SJ, Cheloha RW.
JACS Au (2024 Dec 23) 4:4780-4789. Abstract/Full Text
Highly biased agonism for GPCR ligands via nanobody tethering.
Sachdev S, Creemer BA, Gardella TJ, Cheloha RW.
Nat Commun (2024 Jun 1) 15:4687. Abstract/Full Text
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Last Reviewed February 2024