Synthetic Bioactive Molecules Section

Using synthetic organic chemistry to create new molecules with unique biological activities.

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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Zheng H, Botos I, Clausse V, Nikolayevskiy H, Rastede EE, Fouz MF, Mazur SJ, Appella DH.
Nucleic Acids Res (2021 Jan 25) 49:713-725. Abstract/Full Text
Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH.
J Am Chem Soc (2019 May 22) 141:8327-8338. Abstract/Full Text
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