Synthetic Bioactive Molecules Section
Using synthetic organic chemistry to create new molecules with unique biological activities.
Select Publications
- Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
- Zheng H, Botos I, Clausse V, Nikolayevskiy H, Rastede EE, Fouz MF, Mazur SJ, Appella DH.
- Nucleic Acids Res (2021 Jan 25) 49:713-725. Abstract/Full Text
- Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
- Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH.
- J Am Chem Soc (2019 May 22) 141:8327-8338. Abstract/Full Text