Translational Research: Screening
Screening for small molecule or non-viral biologics may involve a variety of approaches at differing scales. Some examples are high throughput screening of millions of small molecules in a cellular assay, testing a few hundred FDA-approved compounds in an ex vivo culture system, or panning through a phage-display library for neutralizing peptides.
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Disease
Biology -
Unvalidated
TargetTarget IDPutative
Targets -
Nominated
TargetAssay DevelopmentScreenable
Assays -
Target AssayScreeningHits and
Starting Points -
HitHit to LeadLead Series
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Lead
CompoundLead
OptimizationPotential
Therapeutic
Leads -
Pre‑clinical
CandidatePre‑clinical
DevelopmentClinical
Therapeutic
Candidate -
Clinical
CandidateClinical
DevelopmentClinical Proof
of Concept -
Licensing and
Commercializa-
tion PartnersMarket-ready
Therapeutics
NIH Funding Opportunities
PA-16-374 NIH external link, Assay Development and Screening to Discover Therapeutic or Imaging Agents for Diseases of Interest to the NIDDK (R01) has expired. The NIDDK is still interested in supporting this type of translational science and another potential option is to apply to the Parent R01 NOFO (PA-20-185 NIH external link) and consider requesting review assignment to any of CSR’s Drug Synthesis, Discovery, Disposition, and Xenobiotics study sections NIH external link, or another relevant review panel. Applicants should consult the NIH/CSR study section descriptions NIH external linkbefore requesting a specific review panel.
Please reach out to one of the Staff Contacts listed below if you have any questions.
Related Resources
- Academic Drug Discovery Consortium External link
- Academic Screening Facilities External link
- NIH Molecular Libraries and Imaging NIH external link
- PubChem NIH external link
- NIDDK Small Business Programs
Staff Contacts
Division of Kidney, Urologic, and Hematologic Diseases
Dr. Anna Sadusky
Division of Digestive Diseases and Nutrition
Dr. Bonnie Burgess-Beusse
Division of Diabetes, Endocrinology, and Metabolic Diseases
Dr. Yan Li