Clinical Trials to Inform Management of  Urologic Chronic Pelvic Pain Syndrome Study (COMPASS)

May 2022 Council

Lead Division/Office

KUH

Point(s) of Contact

Christopher Mullins, Ph.D.; Ziya Kirkali, M.D.; Julia Barthold, M.D.

Executive Summary

Urologic Chronic Pelvic Pain Syndrome (UCPPS), characterized by pain in the pelvic region usually associated with diverse urologic symptoms, is widely prevalent and highly debilitating for men and women. Despite numerous past clinical trial efforts there are currently no broadly effective therapies and clinical management is often based on trial and error. The proposed Clinical Trials to Inform Management of Urologic Chronic Pelvic Pain Syndrome Study (COMPASS) will leverage critical new insights into patient phenotypes and associated clinical and biological contributors from the NIDDK’s MAPP Research Network and the broader field to conduct a series of novel clinical trials for UCPPS that overcome limitations of past, traditional, trial designs. The COMPASS program founded in this evidence-driven approach is expected to provide critical progress in defining new and effective clinical management strategies for UCPPS.