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Human Islet Research Network-Consortium on Modeling of Autoimmune Diabetes (HIRN-CMAD) (HIRN-CMAI/CHIB Phase III)

May 2022 Council

Lead Division/Office

DEM

Point(s) of Contact

Albert Hwa, Ph.D.

Executive Summary

Research from the HIRN-Consortium on Modeling Autoimmune Interactions (CMAI) and HIRN-Consortium on Human Islet Biomimetics (CHIB) has made tremendous progress in establishing reagents, tools, and models to study immune mediated diabetes. The proposed new HIRN-Consortium on Modeling of Autoimmune Diabetes (CMAD) will build upon these technologies to further our understanding of how human type 1 diabetes develops. We expect the consortium will develop and optimize models to study how the immune system develops and deviates toward autoimmunity in T1D. These models may also be used to study triggers that begins the changes in islet cells and how that leads to immune cell interactions and beta cell mass decline. These models will also serve as platforms to test and accelerate the translational of T1D interventions.