Acute Kidney Injury
The mechanisms and pathophysiology underlying AKI and its progression.
The Acute Kidney Injury (AKI) program supports basic, translational, and clinical studies on pathogenesis, prevention, and treatment. Fundamental research addresses renal cell response to acute injury or toxic exposure, renal vascular alterations, and mechanisms involved in recovery, repair and regeneration. The portfolio aims to develop functional, structural, and imaging markers for diagnosis, early detection, severity, prognosis, and outcomes. Also of interest is research on the natural history of AKI, including studies on risk and outcome stratification, for early stages and progression to chronic kidney disease.
NIDDK Program Staff
Recent Funding OpportunitiesView More Recent Funding Opportunities
George M. O'Brien Kidney National Resource Centers (U54 - Clinical Trial Not Allowed)
National Coordinating Center for the George M. OBrien Kidney National Resource Centers (U24 - Clinical Trial Not Allowed)
NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed)
PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
NIDDK carries forward the activities developed under NKDEP to meet ongoing need.
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities