Urine Albumin Standardization

Along with estimated GFR, urine albumin measurement and reporting is critical to the early detection and treatment of chronic kidney disease. Lack of standardization of urine albumin measurement and reporting makes it difficult for providers to effectively use test results to inform treatment decisions and monitor kidney health.

Measurement and Reporting Issues

  • Multiple of test options (ex: albumin, albumin-to-creatinine ratio, etc.)
  • Confusion about the type of urine sample to collect (ex: random, timed, overnight, or 24-hour)
  • Lack of international reference material and no standardized urine albumin measurement procedures
  • No standardized reporting units
  • Arbitrary single cut-off value (30 mg/g) vs. specific cut-off values (ex: gender, race, and age)

Working Towards Standardization

In March 2007, NIDDK and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) convened a group of international experts. The group began framing the issues associated with the urine albumin/creatinine ratio measurement and developing a plan to improve harmonization and standardization of the test.

NIDDK, IFCC, and other meeting participants are working to address agreed upon priorities. They also have written a manuscript outlining the issues and a proposed research agenda.

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Learn more about the NIDDK Laboratory Working Group and read recent meeting minutes.