Obesity Treatment & Prevention
Behavioral, pharmacological and surgical approaches; research evaluating environmental, policy, and population-based prevention strategies.
The Obesity Treatment and Prevention program supports research on the prevention and treatment of overweight and obesity across the lifespan. Research focuses on critical periods for excess weight gain or high-risk populations.
Prevention research includes studies of treatment approaches to stop the initial development of overweight/obesity or to prevent additional weight or fat gain in those already overweight or obese. These approaches include behavioral, lifestyle, or environmental interventions to improve diet, decrease sedentary behavior, and increase physical activity. Treatment research focuses on clinical trials that evaluate different approaches to losing weight, improving BMI percentile in growing children, or maintaining weight loss. These interventions involve behavioral, pharmacologic, and surgical approaches.
Research to understand and address psychosocial risk factors related to weight management is also supported. For example, obesity research addressing binge eating, stress, impulsivity, and the influence of social networks might be supported if the primary aim is to improve weight management.
The program also promotes research testing environmental, policy-based, and population-based approaches to the prevention and treatment of obesity, including studies evaluating the impact of programs or policies on diet, physical activity, or obesity development.
NIDDK Program Staff
Recent Funding OpportunitiesView More Recent Funding Opportunities
NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed)
PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
Promoting Organ and Tissue Donation Among Health Disparity Populations (R01 - Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.