Etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications.
The Cystic Fibrosis Research program supports both basic and clinical studies on the etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications. These studies examine the characterization of the cystic fibrosis gene, its mutations, and the molecular mechanisms by which mutations cause dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Also included are studies aimed at the elucidation of electrolyte transport pathways in affected epithelia, their relationship to the CFTR, and research on the potential roles of CFTR in the transport of molecules in critical cellular processes. The ultimate goal of these mechanistic studies is to develop therapies that modulate the transport defect and improve the functioning of mutant CFTR. Other research is conducted to determine the relationship between genotype and phenotype (e.g., variable clinical presentations and severity of disease) and to delineate the mechanisms underlying the disease’s characteristic inflammation and infection, with the ultimate goal of developing safe and effective methods of therapy for individuals with cystic fibrosis.
NIDDK Program Staff
- Thomas Eggerman, M.D., Ph.D. Cystic fibrosis research and translation centers, Cystic Fibrosis basic research and clinical trials, rare metabolic diseases basic and clinical trials, clinical islet transplantation registry; advanced artificial pancreas clinical trials, post COVID-19 new onset diabetes
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Notice of Special Interest (NOSI): Encouraging Health Disparities and Health Equity Workforce Development within NIDDK Mission Areas
Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)
Impact of Comorbidities and Co-Infections on HIV Reservoirs (R01 Clinical Trial Not Allowed)
NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)
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Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
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Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
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