Diabetes, Endocrine, & Metabolic Disease Translational Research
Studies that translate scientific findings into practice to enhance human health of those with, or at risk for, metabolic disease.
The Diabetes, Endocrine, and Metabolic Disease Translational Research program promotes studies to advance basic science towards practical applications leading to improvements in the diagnosis and treatment of diseases of interest to the Division of Diabetes, Endocrinology, & Metabolic Diseases at the NIDDK such as obesity, type 1 and type 2 diabetes and related aspects of endocrinology and metabolism, other metabolic disorders, and specific aspects of cystic fibrosis. The program encourages efforts to develop the sound evidence base needed to advance proteomic, metabolomic, genomic, epigenomic, and other ‘omic findings towards applications to clinical studies, such as for precision medicine. Additionally, this program encompasses the development of the necessary supporting technologies to accomplish those goals. Studies that fall within this program may include: the identification of genes and epigenetic factors that influence variable pharmacodynamic and pharmacokinetic responses to therapeutic agents; systems biology approaches to determine how higher-level properties of complex biological systems arise from the interactions among their parts; interdisciplinary therapeutics discovery research to advance the validation of targets (see the therapeutics discovery pipeline here); and the identification of pre-therapeutic candidates through the development and implementation of drug discovery assays. Of particular interest to this program are models that are capable of predicting disease risk or therapeutic efficacy.
NIDDK Program Staff
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Ellen Leschek, M.D. Type 1 and type 2 diabetes clinical research
- Yan Li, Ph.D. Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.
- Salvatore Sechi, Ph.D. Proteomics, Systems Biology, and Structural Biology as applied to diabetes, metabolic, and endocrine diseases
- Lisa M. Spain, Ph.D. Disease-modifying clinical trials in type 1 diabetes, etiology and pathogenesis of type 1 diabetes
Recent Funding OpportunitiesView More Recent Funding Opportunities
Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)
Notice of Special Interest (NOSI): Implementation Science to Advance Maternal Health and Maternal Health Equity for the IMPROVE initiative
Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)
Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.