Diabetes & Metabolism HIV/AIDS
Studies on the metabolic complications of HIV infection and treatment, including endocrine and body composition abnormalities.
The Diabetes and Metabolism HIV/AIDS program supports innovative basic science and clinical research on the role of HIV infection, including relevant host conditions, or antiretroviral therapy (ART) on metabolic and endocrine dysfunction. Specific areas of support include, but are not limited to:
- Studies to elucidate the mechanisms underlying the effects of HIV and/or ART on metabolism (including glucose, lipid, and skeletal metabolism), body composition, and general endocrine function through basic and clinical research
- Studies that elucidate novel approaches to prevent or manage diabetes and/or other endocrine disorders in HIV-infected individuals. However, such studies should target pathways unique to the development of these disorders in the context of HIV infection and/or its treatment rather than simply testing treatments accepted in non-HIV-infected individuals
- Studies that elucidate the interactions between HIV, ART, and/or HIV-associated inflammation and diabetes-related medications to provide a basis for individualized therapy
- Studies that determine the extent to which HIV and its therapy increase the risk of diabetes and/or other endocrine or metabolic dysfunction and identify factors which augment or ameliorate the risk
- Studies that discover and validate biomarkers for metabolic and/or endocrine disease progression as a result of HIV infection or its treatment
- Studies that employ non-invasive or minimally invasive means to assess tissue-specific or whole body metabolic changes in vivo due to HIV infection or therapy
Animal studies will not be considered except for those in non-human primates.
NIDDK Program Staff
- Saul Malozowski, M.D., Ph.D., M.B.A. Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism; HIV/AIDS-associated metabolic and endocrine dysfunction
- Khoa Nguyen, PharmD HIV/AIDS comorbidities, complications, coinfections
Recent Funding OpportunitiesView More Recent Funding Opportunities
Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)
Notice of Special Interest (NOSI): Implementation Science to Advance Maternal Health and Maternal Health Equity for the IMPROVE initiative
Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)
Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
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- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
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- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
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