Metabolic Pathways

Studies on the pathways that are involved in intermediary metabolism as they impact endocrine and metabolic diseases.

NIDDK Program Staff

  • Kristin M. Abraham, Ph.D. Development of resources and infrastructure to support provision and exploration of human tissues for studies of diabetes, and improvements in innovative mouse models to advance diabetes research.
  • Dhananjay (Jay) Gupta, Ph.D., M.S. Basic research on pathogenesis of obesity and Type 2 Diabetes; Role of gene-environment interaction in regulation of metabolism; Transcriptional regulation of gene expression; Cellular signaling pathways regulating intermediary metabolism and cellular identity
  • Carol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic disease
  • Maren Laughlin, Ph.D. Energy balance, thermogenesis and mitochondria biology, whole body intermediary carbohydrate, lipid and protein metabolism, and functional and metabolic imaging in adipose, pancreas and other metabolic organs.
  • Hanyu Liang, M.D., Ph.D. Hepatic Metabolism; Insulin Resistance; Type 2 Diabetes; Obesity; Bariatric Surgery

Recent Funding Opportunities

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  1. RFA-DK-23-021

    Cardiovascular Repository Type 1 Diabetes (CARE-T1D) Consortium (U01 Clinical Trial Not Allowed).

  2. RFA-DK-25-001

    Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional)

  3. RFA-DK-25-002

    Single Source for continuation of the Human Pancreas Analysis Program for Type-2 Diabetes (HPAP-T2D) (U01 Clinical Trial Not Allowed)

  4. RFA-OD-24-004

    Federated Biobanking resource for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project (U24 Clinical Trial Not Allowed)

  5. RFA-OD-24-005

    Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) (U54 Clinical Trial Not Allowed)

View More Recent Funding Opportunities
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  • Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.

Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

  • Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
  • NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
  • NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

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NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

Learn about NIDDK Research Training Programs


Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.

Learn about NIDDK Diversity Programs

Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

Learn about NIDDK Small Business Programs

Human Subjects Research

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

Learn about Human Subjects Research

Translational Research

Translational Research process graphic

NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

Learn about NIDDK Translational Research Opportunities

Meetings & Workshops

  • NIH Common Fund

    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.

  • Planning to Apply? Register Early

    Registration is required at eRA Commons and and can take 4 weeks.