Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.
NIDDK Program Staff
- Kristin M. Abraham, Ph.D. The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotyping
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
- Miranda Broadney, M.D., M.P.H. Pediatrics, Pediatric Endocrinology, Clinical Management of Diabetes Mellitus, Insulin Resistance, Pediatric Obesity
- Maren Laughlin, Ph.D. Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
- Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; human studies of metabolic imprinting
- Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease; Diabetes Research Centers
- Lisa M. Spain, Ph.D. Disease-modifying clinical trials in type 1 diabetes, etiology and pathogenesis of type 1 diabetes
- Karen L. Teff, Ph.D. Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes
Recent Funding Opportunities
View More Recent Funding Opportunities-
NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed)
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Stakeholder Engagement Innovation Center for Advancing Health Equity in Type 2 Diabetes Research (U2C - Clinical Trial Not Allowed)
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Limited Competition for the Continuation of the NIDDK Diabetic Foot Consortium - Clinical Research Units (U01 Clinical Trial Optional)
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PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
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PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
Related Links
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View related clinical trials from ClinicalTrials.gov.
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Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
Research Resources
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
Research Training
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training ProgramsDiversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity ProgramsSmall Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.
Learn about NIDDK Small Business ProgramsHuman Subjects Research
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects ResearchTranslational Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.
Learn about NIDDK Translational Research Opportunities-
NIH Common Fund
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
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Planning to Apply? Register Early
Registration is required at eRA Commons and grants.gov and can take 4 weeks.