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Pathophysiology of Diabetes & Metabolic Disease

Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.

NIDDK Program Staff

  • Kristin M. Abraham, Ph.D. The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotyping
  • Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
  • Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
  • Miranda Broadney, M.D., M.P.H. Pediatrics, Pediatric Endocrinology, Clinical Management of Diabetes Mellitus, Insulin Resistance, Pediatric Obesity
  • Maren Laughlin, Ph.D. Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
  • Hanyu Liang, M.D., Ph.D. Hepatic Metabolism; Insulin Resistance; Type 2 Diabetes; Obesity; Bariatric Surgery
  • Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; human studies of metabolic imprinting
  • Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease; Diabetes Research Centers
  • Lisa M. Spain, Ph.D. Disease-modifying clinical trials in type 1 diabetes, etiology and pathogenesis of type 1 diabetes

Recent Funding Opportunities

View More Recent Funding Opportunities
  1. RFA-DK-22-017

    NIDDK Information Network Coordinating Unit: dkNET-CU (U24 Clinical Trial Not Allowed)

  2. RFA-DK-22-039

    Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)

  3. NOT-HD-22-043

    Notice of Special Interest (NOSI): Implementation Science to Advance Maternal Health and Maternal Health Equity for the IMPROVE initiative

  4. PAR-22-129

    Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

  5. RFA-DK-22-020

    Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)

View More Recent Funding Opportunities

Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

  • Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
  • NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
  • NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

Funding Eligibility by Career Level arrow graphic

NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

Learn about NIDDK Research Training Programs

Diversity

Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.

Learn about NIDDK Diversity Programs

Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

Learn about NIDDK Small Business Programs

Human Subjects Research

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

Learn about Human Subjects Research

Translational Research

Translational Research process graphic

NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

Learn about NIDDK Translational Research Opportunities

Meetings & Workshops

  • NIH Common Fund

    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.

  • Planning to Apply? Register Early

    Registration is required at eRA Commons and grants.gov and can take 4 weeks.