Pathophysiology of Diabetes & Metabolic Disease

Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.

The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. This Program also includes studies that address the etiology of type 1 diabetes and other autoimmune endocrine diseases, such as autoimmune thyroid disease.

This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. Also included are studies that use innovative technologies, such as genetic and epigenetic analyses, systems biology, and bioengineering, to understand the biological networks of underlying disease, with the goal of developing novel therapeutic strategies.

NIDDK Program Staff

Kristin M. Abraham, Ph.D. The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotyping
Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
Miranda Broadney, M.D., M.P.H. Pediatrics, Pediatric Endocrinology, Clinical Management of Diabetes Mellitus, Insulin Resistance, Pediatric Obesity
Maren Laughlin, Ph.D. Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
Hanyu Liang, M.D., Ph.D. Hepatic Metabolism; Insulin Resistance; Type 2 Diabetes; Obesity; Bariatric Surgery
Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; human studies of metabolic imprinting
Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease; Diabetes Research Centers
Lisa M. Spain, Ph.D. Disease-modifying clinical trials in type 1 diabetes, etiology and pathogenesis of type 1 diabetes

Recent Funding Opportunities

View More Recent Funding Opportunities

Posted: 11/30/2022 RFA-DK-22-017

NIDDK Information Network Coordinating Unit: dkNET-CU (U24 Clinical Trial Not Allowed)

Summary
Posted: 10/21/2022 RFA-DK-22-039

Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)

Summary
Posted: 9/19/2022 NOT-HD-22-043

Notice of Special Interest (NOSI): Implementation Science to Advance Maternal Health and Maternal Health Equity for the IMPROVE initiative

Summary
Posted: 9/12/2022 PAR-22-129

Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

Summary
Posted: 9/1/2022 RFA-DK-22-020

Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)

Summary

View More Recent Funding Opportunities

Type 1 Diabetes Special Statutory Funding Program
NIDDK Active Trials in Diabetes and Metabolic Disease

View related clinical trials from ClinicalTrials.gov.
NIH Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.

Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

Learn about NIDDK Research Training Programs

Diversity

Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.

Learn about NIDDK Diversity Programs

Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

Learn about NIDDK Small Business Programs

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

Learn about Human Subjects Research

Translational Research

NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

Learn about NIDDK Translational Research Opportunities

Meetings & Workshops

Roll-up image for the Pre-Application Webinar and Frequently Asked Questions (FAQs) for RFA-DK-22-017 and RFA-DK-22-018

Pre-Application Webinar and Frequently Asked Questions (FAQs) for RFA-DK-22-017 "NIDDK Information Network Coordinating Unit" and RFA-DK-22-018 Pancreas Knowledgebase Program

Dec. 6 - 13, 2022
Webinar

NIDDK K Awardees' Workshop

April 20 - 21, 2023
Bethesda, MD

dkNET

Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.

View all Meetings & Workshops

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
Planning to Apply? Register Early

Registration is required at eRA Commons and grants.gov and can take 4 weeks.

Pathophysiology of Diabetes & Metabolic Disease

NIDDK Program Staff

Recent Funding Opportunities

NIDDK Information Network Coordinating Unit: dkNET-CU (U24 Clinical Trial Not Allowed)

Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)

Notice of Special Interest (NOSI): Implementation Science to Advance Maternal Health and Maternal Health Equity for the IMPROVE initiative

Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)

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